Investigation of Hydrodynamic Flow Characteristics in Helical Coils with Ovality and Wrinkles

The forming of helical coils using a rolling process results in geometrical irregularities (wrinkles and ovality) that are likely to influence the hydrodynamic behaviour of the flow field inside the coil in applications such as air generators. In this study, the above behaviour was investigated by experimental and numerical analyses considering the heat exchanger used in dry air generators. In experimental analysis, a three-turn copper helical coil with wrinkles and ovality was investigated to estimate the global hydrodynamic characteristics inside the helical coil. The results were compared with that of the ideal geometry of a coil without wrinkles and ovality. The effect of wrinkles was assessed through friction factor, and the corresponding equivalent surface roughness was found to increase by 5.7 times, owing to the presence of wrinkles in the helical coil. Numerical simulation was conducted to determine the pressure distribution, velocity distribution, and secondary flow inside the helical coil; the results were validated with experimental data. A critical portion of the helical coil with multiple wrinkles was considered for numerical simulation to investigate the localized effects of wrinkles on the flow field behaviour. The analysis in the vicinity of wrinkles revealed negative pressure development during flow, which in turn would cause re-circulation and cavitation that are undesirable.

Postoperative outcomes and the association with overlap before or after the critical step of lumbar fusion

OBJECTIVE This study assesses how degree of overlap, either before or after the critical operative portion, affects lumbar fusion outcomes. METHODS The authors retrospectively studied 3799 consecutive patients undergoing single-level, posterior-only lumbar fusion over 6 years (2013–2019) at a university health system. Outcomes recorded within 30–90 and 0–90 postoperative days included emergency department (ED) visit, readmission, reoperation, overall morbidity, and mortality. Furthermore, morbidity and mortality were recorded for the duration of follow-up. The amount of overlap that occurred before or after the critical portion of surgery was calculated as a percentage of total beginning or end operative time. Subsequent to initial whole-population analysis, coarsened exact-matched cohorts of patients were created with the least and most amounts of either beginning or end overlap. Univariate analysis was performed on both beginning and end overlap exact-matched cohorts, with significance set at p < 0.05. RESULTS Equivalent outcomes were observed when comparing exact-matched patients. Among the whole population, the degree of beginning overlap was correlated with reduced ED visits within 30–90 and 0–90 days (p = 0.007, p = 0.009; respectively), and less 0–90 day morbidity (p = 0.037). Degree of end overlap was correlated with fewer 30–90 day ED visits (p = 0.015). When comparing only patients with overlap, degree of beginning overlap was correlated with fewer 0–90 day reoperations (p = 0.022), and no outcomes were correlated with degree of end overlap. CONCLUSIONS The degree of overlap before or after the critical step of surgery does not lead to worse outcomes after lumbar fusion.

Design of Piping Systems for Accidental Explosion and Fire Events

Piping systems constitute the most critical portion of process plants. Proper blast and fire design of critical piping systems improve safety and resiliency. Design of piping and pipe supports are typically governed by operating and abnormal load conditions depending on the design basis. Well established analysis and design methodologies as per the applicable ASME codes ensure performance of piping systems against load cases such as internal pressure, thermal expansion, self-weight, wind, seismic and vibration. Pipe stress analysis using code based linear elastic analysis methods allow design for these types of conventional load cases in a practical way. However, beyond design basis load cases from hydrocarbon accidents including explosion and fires can pose additional challenges. Limitations of conventional design tools against demands due to extreme events require use of more advanced techniques. This study presents a practical approach for assessment and design of piping systems for hydrocarbon accident events. Performance based failure criteria for piping systems has been shown to reduce the conservatism compared to allowable stress design for extreme events. Examples from major projects and case studies are also presented to demonstrate the technical approach. Consideration of a holistic approach accounting for interaction of piping and its support structure plays a key role in improving the design process.

Complexity and Significance: A Sequential Analysis on the Conduct of Research

Research is a mission for trust with the assistance of study, acknowledgment, association, and preliminaries in the journey for information through the goal and proficient methodology to discover answers for an issue. The examination decides and breaks down the degree of appraisal seen by the understudies as far as the complexity and significance of the research. The examination respondents were the 252 understudies from Marketing and Human Resource Management courses utilizing the descriptive survey method as a research instrument on a simple random sampling. Frequency and simple percentage, and Mode were used to summarize, separate, and unravel the information. The discovery uncovered that understudies gigantically experienced complexities recorded in composing the proposition, leading the exploration, and managing the research paper. The study concludes that research is a critical portion of understudies’ learning cycle and incredibly adds to making College undertaking more compelling in imparting long lasting learning. Departmental Research courses and workshops are to be practiced to hone understudies’ degree of commitment and mindfulness concerning Research. Emphasis on the significance of research among understudies is a thing to be perceived to persuade them to seek after research, notwithstanding the struggles that they may experience.

Using Text Mining to Compare Research to Practice in the Use of a Social Networking Platform for Pain Management of Genetic Disorders

Social media allows for the creation of communities of interest around a wide variety of medical conditions; one example of which is pain management. Pain management is a critical portion of the overall healthcare system, as evidenced by the pervasive opioid crisis in the United States. One population that struggles with pain management is communities that experience genetic disorders. The goal of this paper is to examine the findings of the extant academic literature regarding pain management for genetic disorders on social media and compare it with the actual posting of people on social media in regard to their chronic pain and pain management. The authors used text mining techniques of the Brandwatch application to analyze the users' posts on different social media platforms such as online discussion forum, blog, Tumblr, Twitter, YouTube, etc. The analysis demonstrates differences in the focus of scholarly inquiry regarding social media with user practice in relation to the topic of pain management.

Indigenizing Social Work: Andragogical Strategies for Incorporating Native Knowledge in Curricula

Though there are more than 5 million American Indian people living in the United States, and they are disproportionately represented among social workers’ clientele, social work curriculum rarely centers Indigenous history and knowledge. Therefore, the cultural competence training that social work students receive is incomprehensive because it often erases a critical portion of the population. This work focuses on the unique knowledge that one Indigenous social work instructor brings to her classroom, as well as the perspective of the BSW director who recruited her to the position. It is critical that the social work profession begin to move toward being representative of the diverse populations that we serve, not only in the field but also in the classroom. This work will provide examples of cultural competence training as well as Indigenous knowledge that can be incorporated into classrooms to indigenize those spaces and decolonize curricula. This article was written jointly by an Indigenous social work professor and an administrator and professor in a BSW program.

Landmark Cases in Forensic Psychiatry

Landmark Cases in Forensic Psychiatry 2nd edition brings together concise, comprehensive summaries of the most important ‘landmark’ legal decisions relating to mental health practice in the United States. These decisions, along with their underlying reasonings, make up a critical portion of the national certification examination for forensic psychiatry offered by the American Board of Psychiatry and Neurology (ABPN). Many of the themes are also tested in the ABPM certification examination for general psychiatry. This text is the first to provide a combination of summaries of the relevant legal content paired with board-style test questions designed to help consolidate knowledge and prepare for certification. Cases with similar themes are grouped together with an eye toward helping the reader understand the evolution of legal and clinical thinking on a particular topic.

Use of Prolapsing Guidewire to Secure Portal Venous Access During the TIPS Procedure

Perhaps the most critical portion of the transjugular intrahepatic portosystemic shunt procedure involves obtaining secure portal venous access. An acute angle of entry into the portal venous system during intrahepatic portosystemic shunt creation can make retrograde advancement of a guidewire into the splenic or superior mesenteric vein difficult. However, securing access from the jugular access site to the portal system with a reliable guidewire is of critical importance during the procedure. This chapter presents a technique to advance a flexible-tip guidewire antegrade into right portal vein branches prior to prolapsing the guidewire into the main portal vein to secure transjugular portal venous access.

Partial ablation of the orexin field induces a sub narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration

Narcolepsy type 1 (Na-1) and 2 (Na-2) are characterized by an inability to sustain wakefulness and are likely caused by degeneration of orexin neurons. Near complete orexin neurodegeneration depletes orexin-A from the cerebrospinal fluid and produces Na-1. The pathophysiology of Na-2 is less understood, but has been hypothesized to be due to less extensive loss of orexin neurotransmission. The orexin-tTA; TetO diphtheria toxin A mouse allows conditional control over the extent and timing of orexin neurodegeneration. To evaluate partial ablation of the orexin field as a model of Na-2, orexin-A positive cell counts and sleep/wake phenotypes (determined by piezoelectric monitoring) were correlated within individual mice after different protocols of diet-controlled neurodegeneration. Partial ablations that began during the first 8 days of study were 14% larger than partial ablations induced during the last 8 days of study, six weeks later and prior to sacrifice of all mice, suggesting orexin-A positive cell death continued despite the resumption of conditions intended to keep orexin neurons intact. Sleep/wake of mice with 71.0% orexin-A positive cell loss, initiated at the beginning of study, resembled that of orexin-intact controls more than mice with near complete neurodegeneration. Conversely, mice with 56.6% orexin-A positive cell loss, created at the end of study, had sleep/wake phenotypes that were similar to those of mice with near complete orexin-A positive cell loss. Collectively, these results suggest that compensatory wake-promotion develops in mice that have some critical portion of their orexinergic system remaining after partial ablation.Statement of significanceThe pathophysiology of narcolepsy type 2 is poorly understood but has been hypothesized to be due, at least in part, to degeneration of a smaller proportion of the orexin neuronal field than occurs in narcolepsy type 1. To evaluate a transgenic mouse model of narcolepsy type 2, we correlated the sleep/wake phenotypes of individual, male and female adult mice that received diet-induced conditional ablations of orexin neurons with their orexin cell counts. Using a translatable measure of narcolepsy sleepiness severity, we demonstrated that compensatory wake-promoting responses developed in mice concurrent with progressive orexin neurodegeneration. These results provide important details necessary for preclinical drug discovery for therapeutic areas characterized by orexin insufficiency, such as narcolepsy, Parkinson’s disease, and other neurodegenerative disorders.

Training cardiac surgeons: the Indiana University experience

In this article, I will outline the origin of cardiothoracic surgical (CTS) training at Indiana University (IU) and its evolution to the present. I will describe my educational background, surgical training in this specialty, and my role as an educator of CT surgeons. I will describe our faculty and the structure of the CTS residency. Finally, I will describe a newly adopted smart phone “App” called SIMPL, which allows the resident and faculty to quickly (<4 minutes) evaluate the CTS resident’s performance for each surgical case they perform together. The tool prompts both parties to determine the resident’s level of involvement in >50% of the most critical aspects of each surgical procedure, the resident’s performance during the critical portion of the operation from poor to excellent, and the degree of difficulty of the operation from simple to complex. The attending surgeon and the resident data are then forwarded to the SIMPL database where the SIMPL software aggregates data for each resident and procedure producing a report at the end of the rotation of the resident’s performance relative to his peers. This additional evaluation process will better ensure that our CTS residents are “practice ready” when they complete their training.