Two-dimensional craniometry: morphometry and cephalometry

Over the last twenty years, bone research has raised interest; the function, shape and alterations of bone tissue have been analyzed and reported. Craniometry is a method developed as a tool for the precise measurement of the skull and facial structures and it has been used not only for humans, but for a variety of mammals. Morphometry is used to study and quantitatively compare the shape variation of biological objects, organs and organisms. Cephalometry uses two-dimensional measurements of the head and face involving a radiographic analysis to provide data on soft tissue, dental and skeletal relationships. Papers regarding bone research are difficult to access and usually, craniometry and morphometry are reported separately. The object of this article is to report a two-dimensional craniometry performed in rats, using both morphometry and cephalometry. This specific craniometry is a functional, well established method which involves the entire anatomical aspects of the skull.

Metabolomics in Bone Research

Identifying the changes in endogenous metabolites in response to intrinsic and extrinsic factors has excellent potential to obtain an understanding of cells, biofluids, tissues, or organisms’ functions and interactions with the environment. The advantages provided by the metabolomics strategy have promoted studies in bone research fields, including an understanding of bone cell behaviors, diagnosis and prognosis of diseases, and the development of treatment methods such as implanted biomaterials. This review article summarizes the metabolism changes during osteogenesis, osteoclastogenesis, and immunoregulation in hard tissue. The second section of this review is dedicated to describing and discussing metabolite changes in the most relevant bone diseases: osteoporosis, bone injuries, rheumatoid arthritis, and osteosarcoma. We consolidated the most recent finding of the metabolites and metabolite pathways affected by various bone disorders. This collection can serve as a basis for future metabolomics-driven bone research studies to select the most relevant metabolites and metabolic pathways. Additionally, we summarize recent metabolic studies on metabolomics for the development of bone disease treatment including biomaterials for bone engineering. With this article, we aim to provide a comprehensive summary of metabolomics in bone research, which can be helpful for interdisciplinary researchers, including material engineers, biologists, and clinicians.

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as the population ages. Traditionally, smart biomaterials have been thought as those that respond to stimuli. However, the continuous evolution of the field warrants a fresh look at the concept of smartness of biomaterials. This review presents a redefinition of the term “Smart Biomaterial” and discusses recent advances in and applications of smart biomaterials for hard tissue restoration and regeneration. To clarify the use of the term “smart biomaterials”, we propose four degrees of smartness according to the level of interaction of the biomaterials with the bio-environment and the biological/cellular responses they elicit, defining these materials as inert, active, responsive, and autonomous. Then, we present an up-to-date survey of applications of smart biomaterials for hard tissues, based on the materials’ responses (external and internal stimuli) and their use as immune-modulatory biomaterials. Finally, we discuss the limitations and obstacles to the translation from basic research (bench) to clinical utilization that is required for the development of clinically relevant applications of these technologies.

The Influence of Organizational Culture on Employee Performance at Bappeda and Statistics of Bone Regency

Fun work culture create a positive employee attitude and gave impetus to work more diligently and more good.Aims this study was to determine the influence of organizational culture on organizational commitment in Bappeda and Statistics of Bone. Research uses explanatory research with a quantitative approach (positivism). Explanatory research explains the causal relationship between variables that influence the hypothesis. The results show that organizational culture has a significant positive effect on employee performance. This organizational culture can be seen from employee empowerment, team orientation, clarity of vision, direction and organizational goals. The stronger the organizational culture, the higher the performance.