CrystEngComm - Invitation to Submit Polymorphism and cocrystal salt formation of 2-((2,6-dichlorophenyl)amino)benzoic acid, harvest of a second form of 2-((2,6-dimethylphenyl)amino)benzoic acid, and isomorphism between the two systems

2-((2,6-Dichlorophenyl)amino)benzoic acid (2-DCABA), a potential non-steroidal anti-inflammatory drug and an analog of 2-((2,6-dimethylphenyl)amino)benzoic acid (HDMPA) was synthesized and its polymorphism was studied to investigate the effect of double Cl-CH3 exchange....

One-pot synthesis of N-benzyl-2-aminobenzoic acid, via ring opening of isatoic anhydride derivative, and its antibacterial screening

2-(N-Benzyl) amino benzoic acid is a bifunctional molecule that could be produced from the reaction between isatoic anhydride and aryl halide. Analogues and derivatives of isatoic anhydride have wide application in pharmaceuticalsincluding antibacterial activity. The aim of this study is to synthesize, characterize and screen N-benzyl isatoic anhydride and 2-(N-benzyl) amino benzoic acid for antibacterial activity. The reaction of isatoic anhydride and benzyl bromide in the presence of potassium carbonate in DMSO at room temperature yielded N-benzyl isatoic anhydride, which under hydrolysis yielded 2-(N-benzyl) amino benzoic acid in which the anhydride ring is opened up. This compound was screened against Gram positive and negative bacteria. Moderate yield of 2-(N-benzyl) amino benzoic acid, a yellow crystal (melting point of 160-162oC, percentage yield 65 %, Rf 0.19) formed by ring opening of N-benzyl isatoic anhydride. The compound showed no antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas pyocyanea, Salmonella typhimurium, Klebsiella aeruginosa and Bacillus subtilis. 2-(N-benzyl)amino benzoic was synthesized, characterized and showed no activity against bacteria.

Two Rival Newly Fabricated Potentiometric Sensors to Enhance Selectivity Toward Cu(II) Ions

Utilizing the well-known ability of Schiff base ligands to bind metal ions, two newly fabricated ligands, namely: 2-((2-hydroxybenzylidene)amino)benzoic acid (L1) and 2-(furan-2-ylmethyleneamino)phenol (L2) were employed to coordinate copper(II) (Cu(II)) producing the characteristically stable complexes that performed as the ionophores in the presently fabricated electrodes A and B. Thus it was possible to build these electrodes that have attractive properties and expected behavior, namely, low detection limits: 2.32 × 10–7 and 1.14 × 10–6 M Cu(II), Nernstian slope of 29.13 and 30.85 mV/decade Cu(II), broad concentration ranges from 3.98 × 10–7–1.00 × 10–2 and 1.52 × 10–6–1.00 × 10–2 M for sensors A and B, respectively, as well as short response time (ca. 3–5 s) with distinct selectivity toward Cu(II) over the other cations and applicability over the pH range 1.5–5.5 for miscellaneous samples: aqueous solutions, urine, and blood serum. Thus, these sensors surpass many others towards fulfilling the intended function of Cu(II) determination in various applications.

Synthesis of Some New Bis- 2, 3-Dihydroquinazolin-4(1H)-one Derivatives from Dapsone Drug and Investigating their Liquid Crystalline Properties and Antibacterial Activities

During this paper, new Schiff's base derivatives [F1-F5] were prepared through the reaction of dapsone drug with different substituted benzaldehyde compounds. Schiff's bases were then converted into 2,3-dihyroquinazolin-4(1H)-one derivatives [F6-F10] through the reaction with 2-amino benzoic acid in ethanol. The synthesized compounds were identified by their physical properties using UV-Vis, FT-IR and 1H-NMR analyses. The liquid crystalline properties of some prepared compounds revealed smectic and nematic phases. Using two separate bacterial species, Pseudomonas aeruginosa (Gram -ve) and Staphylococcus aureus (Gram +ve), the antimicrobial activities of certain synthesized compounds [F1,F2,F7,F8] were investigated using the agar diffusion process. The findings revealed that some of the assayed compounds had antimicrobial activities against the bacteria tested.

Design, Synthesis of a Novel Banana-Shaped Compounds via Esterification

Schiff's Bases were synthesized from the reaction of p-amino benzoic acid and alkoxybenzaldehyde in absolute ethanol and reacted with (E)-3-((4-hydroxybenzylidene) amino) phenol used DCC (N,N'-Dicyclocarbodiimide) and DAMP (4-(Dimethylamino) pyridine ) to 3-(((E)-4-((4-(((E)-4 alkoxy benzylidene) amino) benzoyl) oxy) benzylidene) amino) phenyl4- (E)- 4-alkoxy benzyli dene ) amino) benzoate. The structures of the products were confirmed by their melting points, FT-IR, 1HNMR spectra.

Purification and Characterization of Polyphenol Oxidase Enzyme from Damson Plum (Prunus insititia) by Spectrophotometrically

Polyphenol oxidase enzyme, performing browning reactions in fruits and vegetables, was purificated from damson plum (Prunus insititia) which has a high antioxidant activity. Firstly, partially purified polyphenol oxidase was treated by 0-80% ammonium sulfate precipitation and dialysis, respectively. Characterization studies were carried out by using catechol, 4-methyl catechol, pyrogallol and caffeic acid as 0.05M/ pH:7.2/ 25°C; 0.2M/ pH:4.5/ 10°C; 0.01M/ pH:6.8/ 5°C and 0.2M/ pH:8.5/ 10°C, respectively. The kinetic constants of Vmax and KM were calculated for the same substrates as 17219.97 U/(mL*min) and 11.67mM; 7309.72 U/(mL*min) and 5mM; 12580.12 U/(mL*min) and 3.74mM; 12100.41 U/(mL*min) and 6.25 mM, respectively. Catechol gave the highest Vmax value when compared to others. In the second step, purification was performed by using Sepharose 4B-L-Tyrosine-p-amino benzoic acid and Sepharose 6B-L-Tyrosine-p-amino benzoic acid affinity gels. A single band of approximately as 50-55 kDa was observed in SDS-PAGE and Native-PAGE. 90 and 10.2 purification folds were obtained for Prunus insititia PPO by the reference Sepharose-4B-L-Tyrosine-p-aminobenzoic acid and original Sepharose-6B-L-Tyrosine-p-aminobenzoic acid gels, respectively. PPO enzyme purification from Prunus insititia by affinity chromatography has not been investigated in literature yet.

synthesis Synthesis and Characterization ( Oxazepine , Thiazine and Quinazoline ) Derivatives and Study the Biological Activity as Antibacteria

This research. Included the preparation. and characterization some novel. Six and seven membered Heterocyclic. Compounds ( oxazepine , thiazine , quinazoline ) The first step in clode react 2-amino-6- methoxybenzothiazole with 4- amino acetophenone to get Schiff base derivative (1). The second step react (1) with 4 -hydroxy acetophenone to get schiff base derivative (2) the last step involve react (2) with ( Phthalic , Maleic , Succinic) anhydride to .get oxazepine derivatives (3,4and 5) also react (2) with(2-amino benzoic acid) and (2-mercaptobenzoic acid ) to get quinazoline (6)and thiazine (7) derivatives respectively .the physical; properties of the prepared; These Compounds. Were Identification (FT-IR) ,(1H-NMR) and (13C-NMR) by spectroscopy thene study their biological effect on two types of bacteria Staphylococcus aureuses (Gram positive) and Escherichia coli (Gram Negative)

COMPLEX COMPOUNDS OF LANTANOIDS WITH 4 - [(2,4-DIMETOXYBENZYL) AMINO] BENZOIC ACID.

The synthesis of complex compounds of 4 - [(2,4-dimethoxybenzyl) amino] benzoic acid (HL) with ions of samarium (III), europium (III), terbium (III), gadolinium (III) and dysprosium (III). According to the data of elemental analysis and thermogravimetry, the obtained complexes are hydrates of the composition LnL3 · nH2O, where n = 0-2. The area of their thermal stability is in the range from 100 ° С to 150 ° С. Electronic and infrared absorption spectra of the ligand and complexes with rare-earth metal ions have been measured. According to the IR spectra, the coordination of the ligand with the metal ion occurs at the carboxyl group. The carboxyl group is bidentate coordinated. To excite luminescence, a line of a mercury lamp with a wavelength of 248 nm was used. The highest luminescence intensity is observed for the coordination compounds Eu3 +, Tb3 +, Sm3 +, and Dy3 +.

Structural, Thermal and Surface Properties of a Formulated Sunscreen: Zn/Al-nitrate Layered Double Hydroxide Intercalated with 4-aminobenzoic Acid

Intercalation of 4-amino benzoic acid (4-AB) into Zn/Al-nitrate layered double hydroxide (ZAL2) to form Zn/Al-4AB (ZALAB) compound was successfully synthesized from nitrate salt by using direct co-precipitation method. ZALAB compound was confirmed by Powder X-ray diffraction (PXRD) pattern with a basal spacing of 15.3 Å. The presence of COO- and C6H5NH2 functional groups of 4-AB at 1,517 and 1,178 cm–1 in Fourier transform infrared (FTIR) spectrum reinforced 4-AB intercalated into the resulting compound. Based on the thermal analysis, 4-AB in ZALAB compound was more stable compared to pure 4-AB. Breuneur, Emmet and Teller/Barret-Joyner-Halenda (BET/BJH) analyses demonstrated that ZALAB compound is a mesopores-type IV compound with 4.25 m2/g surface area. This material is an irregular shape with different sizes of particles. ZALAB is a potential sunscreen formulation that minimizes the harmful effect on the skin, improving pharmaceutical technology in the skincare treatment. HIGHLIGHTS 4-amino benzoic acid (4-AB) is a sunscreen composed of carboxylic and aromatic groups that potentially filter UV-B radiation Layered double hydroxide (LDH) is known as an ionic clay that is based on the brucite (Mg (OH)2) -like cations layers containing intercalated charge-balancing anions and water Intercalation of 4-amino benzoic acid (4-AB) into Zn/Al-nitrate layered double hydroxide (ZAL2) to form Zn/Al-4AB (ZALAB) was synthesized using direct co-precipitation method ZALAB material has a higher thermal stability compared to 4-AB in pure form GRAPHICAL ABSTRACT