An Overview on Actual Knowledge About Immunohistochemical and Molecular Features of Vitality, Focusing on the Growing Evidence and Analysis to Distinguish Between Suicidal and Simulated Hanging

In forensic practice, the pathologist is often asked to determine whether a hanging was committed as suicide or as a simulated hanging (when a dead body is suspended after death). When exterior evidence of violence is absent and the crime scene investigation fails to identify useful proof, it is nearly impossible to tell whether the dead body was suspended or not. As a result, determining whether the ligature mark was created during life or not should rely on the research and demonstration of vital reactions on the ligature mark. The main purpose of this review article is to provide a summary of current knowledge about the histological and immunohistochemical characteristics of vitality in hanging. The authors also aim to identify the most significant vitality markers on ligature marks for further scientific validation and to propose a standardized diagnostic protocol for hanging. The study was conducted according to the Preferred Reporting Items for Systematic Review (PRISMA) Protocol. Relevant scientific papers were found from PubMed up to April 2021, using the following keywords: hanging AND skin AND vitality. Three main points were studied: ligature mark dehydration, immunological response to mechanical injury, and apoptosis induction as a result of the previous points. An increase in apoptosis is evident in the ligature mark (due to physical and chemical processes involved), as demonstrated by FLICE-inhibitory protein (FLIP) depletion. Immunohistochemical detection of Aquaporin 3 (AQP3) and increase in the concentration of different electrolytes rely solely on ligature mark dehydration. Also, microRNAs (MiRNAs) could become reliable forensic biomarkers for ligature mark vitality diagnosis in the near future. To ensure high reliability in court cases, forensic investigation in hanging should rely on modern and proven markers, even a mix of several markers.

Innovating the Construction Life Cycle through BIM/GIS Integration: A Review

The construction sector is in continuous evolution due to the digitalisation and integration into daily activities of the building information modelling approach and methods that impact on the overall life cycle. This study investigates the topic of BIM/GIS integration with the adoption of ontologies and metamodels, providing a critical analysis of the existing literature. Ontologies and metamodels share several similarities and could be combined for potential solutions to address BIM/GIS integration for complex tasks, such as asset management, where heterogeneous sources of data are involved. The research adopts a systematic literature review (SLR), providing a formal approach to retrieve scientific papers from dedicated online databases. The results found are then analysed, in order to describe the state of the art and suggest future research paths, which is useful for both researchers and practitioners. From the SLR, it emerged that several studies address ontologies as a promising way to overcome the semantic barriers of the BIM/GIS integration. On the other hand, metamodels (and MDE and MDA approaches, in general) are rarely found in relation to the integration topic. Moreover, the joint application of ontologies and metamodels for BIM/GIS applications is an unexplored field. The novelty of this work is the proposal of the joint application of ontologies and metamodels to perform BIM/GIS integration, for the development of software and systems for asset management.

Determining Research Priorities for Astronomy Using Machine Learning

We summarize the first exploratory investigation into whether Machine Learning techniques can augment science strategic planning. We find that an approach based on Latent Dirichlet Allocation using abstracts drawn from high-impact astronomy journals may provide a leading indicator of future interest in a research topic. We show two topic metrics that correlate well with the high-priority research areas identified by the 2010 National Academies’ Astronomy and Astrophysics Decadal Survey. One metric is based on a sum of the fractional contribution to each topic by all scientific papers (“counts”) while the other is the Compound Annual Growth Rate of counts. These same metrics also show the same degree of correlation with the whitepapers submitted to the same Decadal Survey. Our results suggest that the Decadal Survey may under-emphasize fast growing research. A preliminary version of our work was presented by Thronson et al.

Epidemiology of West Nile virus in Africa: An underestimated threat

Background West Nile virus is a mosquito-borne flavivirus which has been posing continuous challenges to public health worldwide due to the identification of new lineages and clades and its ability to invade and establish in an increasing number of countries. Its current distribution, genetic variability, ecology, and epidemiological pattern in the African continent are only partially known despite the general consensus on the urgency to obtain such information for quantifying the actual disease burden in Africa other than to predict future threats at global scale. Methodology and principal findings References were searched in PubMed and Google Scholar electronic databases on January 21, 2020, using selected keywords, without language and date restriction. Additional manual searches of reference list were carried out. Further references have been later added accordingly to experts’ opinion. We included 153 scientific papers published between 1940 and 2021. This review highlights: (i) the co-circulation of WNV-lineages 1, 2, and 8 in the African continent; (ii) the presence of diverse WNV competent vectors in Africa, mainly belonging to the Culex genus; (iii) the lack of vector competence studies for several other mosquito species found naturally infected with WNV in Africa; (iv) the need of more competence studies to be addressed on ticks; (iv) evidence of circulation of WNV among humans, animals and vectors in at least 28 Countries; (v) the lack of knowledge on the epidemiological situation of WNV for 19 Countries and (vii) the importance of carrying out specific serological surveys in order to avoid possible bias on WNV circulation in Africa. Conclusions This study provides the state of art on WNV investigation carried out in Africa, highlighting several knowledge gaps regarding i) the current WNV distribution and genetic diversity, ii) its ecology and transmission chains including the role of different arthropods and vertebrate species as competent reservoirs, and iii) the real disease burden for humans and animals. This review highlights the needs for further research and coordinated surveillance efforts on WNV in Africa.

Comparison between Heat Flow Meter (HFM) and Thermometric (THM) Method for Building Wall Thermal Characterization: Latest Advances and Critical Review

It is well-known that on-site measurements are suitable for verifying the actual thermal performance of buildings. Performance assessed in situ, under actual thermal conditions, can substantially vary from the theoretical values. Therefore, experimental measurements are essential for better comprehending the thermal behavior of building components, by applying measurement systems and methods suitable to acquire data related to temperatures, heat flows and air speeds both related to the internal and external environments. These data can then be processed to compute performance indicators, such as the well-known thermal transmittance (U-value). This review aims at focusing on two experimental techniques: the widely used and standardized heat flow meter (HFM) method and the quite new thermometric (THM) method. Several scientific papers were analyzed to provide an overview on the latest advances related to these techniques, thus providing a focused critical review. This paper aims to be a valuable resource for academics and practitioners as it covers basic theory, in situ measurement equipment and criteria for sensor installation, errors, and new data post-processing methods.

Analyzing COVID-19 Medical Papers Using Artificial Intelligence: Insights for Researchers and Medical Professionals

Since the beginning of the COVID-19 pandemic almost two years ago, there have been more than 700,000 scientific papers published on the subject. An individual researcher cannot possibly get acquainted with such a huge text corpus and, therefore, some help from artificial intelligence (AI) is highly needed. We propose the AI-based tool to help researchers navigate the medical papers collections in a meaningful way and extract some knowledge from scientific COVID-19 papers. The main idea of our approach is to get as much semi-structured information from text corpus as possible, using named entity recognition (NER) with a model called PubMedBERT and Text Analytics for Health service, then store the data into NoSQL database for further fast processing and insights generation. Additionally, the contexts in which the entities were used (neutral or negative) are determined. Application of NLP and text-based emotion detection (TBED) methods to COVID-19 text corpus allows us to gain insights on important issues of diagnosis and treatment (such as changes in medical treatment over time, joint treatment strategies using several medications, and the connection between signs and symptoms of coronavirus, etc.).

Soil Carbon Sequestration in Novel Ecosystems at Post-Mine Sites—A New Insight into the Determination of Key Factors in the Restoration of Terrestrial Ecosystems

Mining activities are one of the main causes of land degradation around the world and reduce the quality of the surrounding ecosystems. Restoration approaches using different vegetations and reclamation methods have been implemented to address this issue. In this review, paper, different studies focusing on the effect of the restoration of mining sites on the accumulation of soil organic carbon (SOC) were analyzed. SOC in reclaimed mining soil (RMS) increased considerably after various restoration efforts were implemented. The amount of SOC accumulated in RMS was mostly influenced by the restoration age, vegetation type, and substrate or type of reclamation used. From the scientific papers analyzed, we found that SOC accumulation increases with restoration age; however, vegetation type and reclamation have varied effects. According to the review, the restoration of mine sites with vegetation resulted in a rate of SOC accumulation ranging from 0.37 to 5.68 Mg SOC ha−1 year−1. Climate conditions influenced the type of vegetation used for restoration. Regrading, liming, NPK fertilization, and seeding a mix of legumes and grasses were the most efficient reclamation techniques. Additionally, the use of grass and legume better facilitates the early accumulation of SOC compared with afforestation. Thus, the selection of appropriate tree species composition, reclamation treatments, and restoration age are the key factors for a high SOC accumulation rate.

Utilization Of the Mendeley Application as Reference Manager For High School Teachers

This study aims to describe how the Mendeley application is used in writing scientific papers by teacher representatives and to see how the effectiveness of using the Mendeley application as a References Manager. The type of research used is descriptive with a qualitative approach. Data collection was carried out by observation and questionnaires. The instruments used to retrieve data were the observation sheet and questionnaire sheet. Data analysis was carried out by reducing the data from observations and questionnaires, then the data from the reduction results were then presented in the form of tables and descriptions, which were then concluded with the results. The results showed that the Mendeley application could be used easily by teachers in compiling articles and the effectiveness of the response to using the Mendeley application as a Reference Manager also received a high percentage of 83%. And the teacher's interest in using the Mendeley application is also high, namely 81%. This is because the teacher said that Mendeley was very easy to use and up to date.

The Development of Learning Material Model in Writing Scientific Papers by Using Guided Inquiry Method at Universitas PGRI Sumatera Barat

This research is motivated by the difficulties of students in determining the topic of scientific writing, difficulties in conveying ideas and limitations of references. This study aims to develop a learning model for writing scientific papers using the guided inquiry method. This type of research is development research. This study uses a 4-D development research design. The results of this study are as follows: (1) the material for writing scientific papers is difficult because students do not understand the concept of Scientific Writing. (2) in developing scientific work students do not yet know the systematics of scientific writing and students often make ineffective sentences (3) students really need freedom in determining writing topics and ideas (4) most students need the concept of learning to write scientific papers, (5) most students need lecturer guidance in their writing, (6) most students need systematic scientific work concepts, (7) most students need lots of references to write scientific papers. Based on the analysis of student needs, it is necessary to develop a Guided Inquiry-Based Scientific Writing Textbook that provides opportunities for students to find their own concept of learning to write scientific papers. Through Guided Inquiry, students are trained to think critically with teacher guidance.

Inferring microbiota functions from taxonomic genes: a review

Deciphering microbiota functions is crucial to predict ecosystem sustainability in response to global change. High-throughput sequencing at the individual or community level has revolutionized our understanding of microbial ecology, leading to the big data era and improving our ability to link microbial diversity with microbial functions. Recent advances in bioinformatics have been key for developing functional prediction tools based on DNA metabarcoding data and using taxonomic gene information. This cheaper approach in every aspect serves as an alternative to shotgun sequencing. Although these tools are increasingly used by ecologists, an objective evaluation of their modularity, portability, and robustness is lacking. Here, we reviewed 100 scientific papers on functional inference and ecological trait assignment to rank the advantages, specificities, and drawbacks of these tools, using a scientific benchmarking. To date, inference tools have been mainly devoted to bacterial functions, and ecological trait assignment tools, to fungal functions. A major limitation is the lack of reference genomes—compared with the human microbiota—especially for complex ecosystems such as soils. Finally, we explore applied research prospects. These tools are promising and already provide relevant information on ecosystem functioning, but standardized indicators and corresponding repositories are still lacking that would enable them to be used for operational diagnosis.