Imaging Characteristics of Invasive Pulmonary Fungal Infection Secondary to Hematological Diseases and Comparison before and after Treatment

Fungal infections have become crucial factors that threaten the prognosis and survival of blood disease patients. Here, we aim to analyze the epidemiological characteristics and early and advanced CT (computed tomography) manifestations of patients with invasive pulmonary fungal infections secondary to blood system diseases. 65 hospitalized patients from October 2018 to October 2020 with invasive pulmonary fungal infections secondary to blood diseases were enrolled. Blood diseases were recorded according to clinical and imaging data, and the serum galactomannan test (GM test) was conducted. Two senior radiologists analyzed the CT data and recorded the distribution of the lesions and CT signs. We analyzed and counted the first chest CT scan images of patients with nodule/mass type secondary to hematological diseases and invasive pulmonary fungal infection. The first CT nodules or mass-type lesions were statistically significant in nodule size, the number of lesions, distribution, and accompanying signs. Pulmonary fungal infection was common in both lungs during 7-day, 14-day, and 30-day follow-up CT. We also found that the nodular mass type was the main manifestation in the positive group of the GM test. Both the positive group and the negative group had the highest incidence of nodules. The incidence of air crescent signs in nodules or mass lesions in the positive group was higher than in the negative group, and the difference was statistically significant. To conclude, follow-up CT signs after antifungal treatment were highly sensitive to the early diagnosis of hematological diseases and secondary invasive pulmonary Eumycetes infection, which could be used for clinical treatment to provide help. GM test results were also related to CT manifestations such as air crescent sign, cavity, and halo sign.

Pathogenicity Comparison Between QX-Type And Mass-Type Infectious Bronchitis Virus To Different Segments of The Oviducts In Laying Phase

BackgroundThe QX-type infectious bronchitis virus (IBV) has become the predominant genotype worldwide in recent years and has caused serious economic losses to the chicken industry. The most significant feature of QX IBV is that its infection in the early growing stage can cause abnormal oviduct development, resulting in a high proportion of ‘false layers’ in poultry flocks of laying hens and breeders. However, few studies have evaluated whether infections of QX-type IBV in laying stages can also cause severe pathological changes in the oviduct. MethodsIn this study, 300-day-old specific-pathogen-free (SPF) chickens were infected either with the QX-type strain QXL or Massachusetts (Mass)-type strain M41 to compare their pathogenicity on different segments of the oviduct. ResultsBoth the QXL and M41 strains successfully replicated in all segments of the oviduct; however, the QXL strain was more highly distributed in mucosal layer and caused severe lesions in the lamina propria, including interstitial dilation, inflammatory cell infiltration, and distinct expansion of tubular glands. Moreover, the QXL strain induced high expression of proinflammatory cytokines and cytotoxic molecules in the majority of segments in the oviduct. Further research found that the QXL strain may affected the formation of shell membranes and eggshells by inhibiting the expression of type I collagen and CaBP-D28k. ConclusionsOur results indicate that the QX-type IBV is more pathogenic than Mass-type IBV to oviduct in laying phase. Collectively, these findings provide detailed information on the pathological changes in different segments of the oviduct in laying phase, which could offer a better understanding about the pathogenicity of IBV.

Intramedullary Spinal Cystic Lesions Mimicking Cavernoma with Spontaneous Myelum Hemorrhage in Children: A Case Report

Background: Intramedullary spinal masses is a rare yet devastating and challenging. One of the biggest difficulty is to reveal the mass type and feature, thus determine the definitive treatment. Despite its difficulties, many controversies persist regarding diagnosis and management. Case Presentation: We report a case of 6 years old female came with gradual right limb weakness for 1 week before admission. It preceded by neck stiffness and for 2 weeks ago. Radiological examination revealed intradural intramedullary mass suggesting a cavernoma at VC1-C2 and VTh12-L1 level. The histopathological results shows unspecified hematoma. Conclusions: Intramedullary tumors in pediatric population is rare and can mimic any other mass lesion. MRI is the mainstay diagnostic tool of this patient. Complete surgical resection is the main goal of treatment, but the histopathologic features is the most important predictor of the functional outcome.

Concentrations of Polychlorinated Biphenyls (PCBs) in Phragmites australis of Shatt AL-Arab River. South of Iraq

ABSTRACT The concentrations of polychlorinated biphenyls (PCBs) were determined from Autumn season 2019 to summer season 2020 at six sites they are: ( Al-Qurna, Al-Deer, Al-Qarma, Al-Ashar, Abu-Al-khasib, Al-Fao ) in Shatt Al-Arab river, Basrah city, south of Iraq. water samples were taken at each site and were analyzed using gas chromatography-mass spectrometry (GC–MASS) type of Agilent 7890A for PCBs levels. The results indicate that PCBs are detected in all Phragmites australis samples and its concentrations range from 1.45 ng/g to 4.11 ng/g , 5.34 ng/g to 7.99 ng/g, 2.19 ng/g to 3.59 ng/g and 0.45 ng/g to 8.09 ng/g in Autumn, Winter, Spring and Summer seasons, respectively. The Al-Qurna and Al-Ashar sites were found to have the lowest and highest mean levels of PCBs concentrations 0.035 ng/g and 0.622 ng/g, respectively. Total congeners PCBs (PCB 18, 29, 31, 28, 44, 52, 101, 141, 149, 138,153, 189, and 194) concentrations at the Phragmite australis samples for all sites ranged from 0.45 ng/g in Al-Qurna station during summer season to 8.09 ng/g in Al-Ashar station during summer season. Σhexa-PCBs and Σtri-PCBs were dominating in comparison with others PCBs congeners. This study is a first of its kind in the region and could have available information and could be used as a baseline study in the future.

Influence of the groundwater level on the bearing capacity of shallow foundations on the rock mass

The presence of the groundwater level (GWL) at the rock mass may significantly affect the mechanical behavior, and consequently the bearing capacity. The water particularly modifies two aspects that influence the bearing capacity: the submerged unit weight and the overall geotechnical quality of the rock mass, because water circulation tends to clean and open the joints. This paper is a study of the influence groundwater level has on the ultimate bearing capacity of shallow foundations on the rock mass. The calculations were developed using the finite difference method. The numerical results included three possible locations of groundwater level: at the foundation level, at a depth equal to a quarter of the footing width from the foundation level, and inexistent location. The analysis was based on a sensitivity study with four parameters: foundation width, rock mass type (mi), uniaxial compressive strength, and geological strength index. Included in the analysis was the influence of the self-weight of the material on the bearing capacity and the critical depth where the GWL no longer affected the bearing capacity. Finally, a simple approximation of the solution estimated in this study is suggested for practical purposes.

Preoperative ultrasound radiomics analysis for expression of multiple molecular biomarkers in mass type of breast ductal carcinoma in situ

Background The molecular biomarkers of breast ductal carcinoma in situ (DCIS) have important guiding significance for individualized precision treatment. This study was intended to explore the significance of radiomics based on ultrasound images to predict the expression of molecular biomarkers of mass type of DCIS. Methods 116 patients with mass type of DCIS were included in this retrospective study. The radiomics features were extracted based on ultrasound images. According to the ratio of 7:3, the data sets of molecular biomarkers were split into training set and test set. The radiomics models were developed to predict the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki67, p16, and p53 by using combination of multiple feature selection and classifiers. The predictive performance of the models were evaluated using the area under the curve (AUC) of the receiver operating curve. Results The investigators extracted 5234 radiomics features from ultrasound images. 12, 23, 41, 51, 31 and 23 features were important for constructing the models. The radiomics scores were significantly (P < 0.05) in each molecular marker expression of mass type of DCIS. The radiomics models showed predictive performance with AUC greater than 0.7 in the training set and test set: ER (0.94 and 0.84), PR (0.90 and 0.78), HER2 (0.94 and 0.74), Ki67 (0.95 and 0.86), p16 (0.96 and 0.78), and p53 (0.95 and 0.74), respectively. Conclusion Ultrasonic-based radiomics analysis provided a noninvasive preoperative method for predicting the expression of molecular markers of mass type of DCIS with good accuracy.

Imaging analysis of 13 rare cases of renal collecting (Bellini) duct carcinoma in northern China: a case series and literature review

Background Collecting (Bellini) duct carcinoma (CDC) is a highly malignant and rare kidney tumor. We report our 12-year experience with CDC and the results of a retrospective analysis of patients and tumor characteristics, clinical manifestations, and imaging features by computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)/CT. Methods Retrospective examination of tumors between January 2007 and December 2019 identified 13 cases of CDC from three medical centers in northern China. All 13 patients underwent CT scan, among which eight underwent dynamic enhanced CT scan, two underwent PET/CT scan, and one underwent magnetic resonance cholangiopancreatography (MRCP) examination. The lesions were divided into nephritis type and mass type according to the morphology of the tumors. Results The study group included ten men and three women with an average age of 64.23 ± 10.74 years. The clinical manifestations were gross hematuria, flank pain, and waist discomfort. The mean tumor size was 8.48 ± 2.48 cm. Of the 13 cases, six (46.2%) were cortical-medullary involved type and seven (53.8%) were cortex–medullary–pelvis involved type. Eleven (84.6%) cases were nephritis type and two (15.4%) were mass type. The lesions appeared solid or complex solid and cystic on CT and MRI. The parenchymal area of the tumors showed isodensity or slightly higher density on unenhanced CT scan in the 13 cases. PET/CT in two cases showed increased radioactivity intake. Evidence of intra-abdominal metastatic disease was present on CT in nine (69.2%) cases. Conclusions The imaging characteristics of CDC differ from those of other renal cell carcinomas. In renal tumors located in the junction zone of the renal cortex and medulla that show unclear borders, slight enhancement, and metastases in the early stage, a diagnosis of CDC needs to be considered. PET/CT provides crucial information for the diagnosis of CDC, as well as for designing treatment strategies including surgery.