In Germany, the integrity concept is applied to important piping systems in most of the nuclear power plants. Regarding the framework of this concept, those damage mechanisms that cannot be controlled by analysis have to be excluded using appropriate measures. In most of the cases, these damage mechanisms are a result of local effects (like loads, medium, material characteristics) that cannot be determined exactly in advance and thus cannot be controlled by analysis, reliably. Examples are strain induced corrosion (LCF area) and corrosion fatigue (HCF area). For cases like these and given medium, suitable materials have to be chosen in combination with optimized design, appropriate manufacturing procedures (incl. welding), construction and operation. The loads and the water chemistry in operation have to be monitored and the effectiveness of the measures has to be verified, regularly, taking into account the actual state of knowledge. Regarding these boundary conditions the fatigue evaluations that have been performed until today seem to be sufficient, as experience shows with piping systems where this procedure has been applied. There are usually no significant failures (indication of failures); failures detected have been attributed to violation of the boundary conditions. With this background, there seems to be no need to change this procedure to safeguard the effect of environment. In this paper, the measures to guarantee integrity in design and operation state are discussed, first. Using the example of a surge line and the comprehensive monitoring results of this system the evaluation of fatigue usage and the assessment of the effect of coolant environment is discussed with reference to the ANL approach. Where the ANL approach is meant to be applied only in the design phase of a new reactor its relevance for the operation phase is cross-checked with real life measurement data. The conclusion summarizes where the effect of coolant environment has to be taken into account and gives advice how to find realistic transients for the design phase of new reactors.