HETEROTRANSPLANTATIONS AND GENOMIC IN CANCER RESEARCH

We performed ,in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and Axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases. Some years later, we found that A.O cells exerted an induced and spontaneous cytotoxicity against SP2 and MBL2 mouse tumoral cells. Recently, we discovered a sea star Igkappa gene with immune properties. This gene was inserted in a CMV(cytomegalovirus) and finally in a plasmid called « young » plasmid. The induced« young » protein exerted a spontaneous cytotoxicity against osteosarcom cells (U2oS cells) against A-375 melanome cells and Hela cells

OBESITY AND ITS RELATIONSHIP WITH CANCER: PART II CANCER

This four-part manuscript briefly reviews the association of obesity with cancer. Part I discussed obesity while this (Part II) will discuss obesity and its impact on cancer. Part III and Part IV will review the association of obesity on fourteen common cancers.

OBESITY AND ITS RELATIONSHIP WITH CANCER: PART IV

Part I thru III discussed obesity, its general relationship with cancer and its specific impact on six cancers, namely those involving the breast, colorectal tissues, esophagus, stomach. gall bladder, and liver. This part (Part IV) deals with obesity and its relationship with cancers of the endometrium, ovary, pancreas, prostate, kidneys, thyroid, and lung. Meningioma and multiple myeloma are also discussed.

OBESITY AND ITS RELATIONSHIP WITH CANCER: PART I OBESITY

Cancer is a lethal disease and a strong barrier to a better life expectancy. It is the first or second leading cause of death before the age of 70 years in 112 of 183 countries. Its incidence and mortality continue to grow rapidly all over the world. This manuscript is divided into four parts. Part I discusses obesity while Part II discusses the relationship between obesity and cancer. Part III and Part IV review the association of obesity on fifteen common cancers.

OBESITY AND ITS RELATIONSHIP WITH CANCER: PART III

Obesity and cancer has been discussed in the first two parts. This part (Part III) deals with six cancers, namely those involving the breast, colorectal tissues, esophagus, stomach. gall bladder, and liver. Their relationship with obesity is discussed. Part IV will look at endometrial, ovarian, pancreatic, prostate, renal, thyroid and lung carcinomas. Meningioma and multiple myeloma are also discussed.

Invasive Squamous Cell Carcinoma of the Cervix in Pregnancy: A Case Report

Cervical squamous cell carcinoma is the most common histological type of carcinoma in the uterine cervix, but during pregnancy is relativity uncommon, with an incidence of 0.8 to 1.5 cases per 10,000 births. Cervical squamous cell carcinoma is the leading cause of death among women aged 35 to 54 years and the second most common cause among women aged 15 to 34 years after breast carcinoma. Most patients are diagnosed at an early stage of the disease, probably due to routine prenatal screening. The occurrence of invasive cervical carcinoma is relatively uncommon in pregnant women. However, cancer treatment during pregnancy currently remains one of the main and biggest therapeutic challenges in cervical cancer. The therapeutic approach should be customized and depends mainly on histology, disease stage, and gestational age. We present a case concerning a 26-year-old woman with invasive moderately differentiated keratinizing squamous cell cervical carcinoma, stage pT2b, N1, M0/ FIGOIIB, during pregnancy (4th lunar month).

ENTIERE IDENTITIES BETWEEN OPHIOCOMINA NIGRA IGKAPPA GENE AND HUMAN IMMUNOGLOBULIN KAPPA LOCUS.NEW ASPECTS OF INVERTEBRATE IGKAPPA GENES (IPA)

Entiere identities between Invertebrate Ophiocomina nigra IGKappa gene and Human IGK gene are confirmed, in the present work, at the level of immunoglobulin domains (constant and variable). The transcriptome of the Ophuirid : Ophiocomina nigra IGKappa gene was discovered recently(1).Since it was synthesized de novo and cloned in a pUC-GW-Kan plasmid (2) which was a gift of Bo Huang laboratories. The original sequence of the IGKappa gene, after cloning, was the following in 5’-3’ :

Fungi and Effect of Fungi on Bodies

The world and Kingdom Fungi involves many of the most important organisms, both in terms of their ecological and economic roles. By breaking down dead organic material, they continue the cycle of nutrients through ecosystems. In addition, most vascular plants could not grow without the symbiotic fungi, or mycorrhizae, that increase their roots and supply essential nutrients. Other fungi provide numerous drugs (such as penicillin and other antibiotics), foods like mushrooms, truffles and morels, and the bubbles in bread, champagne, and beer.