Basics: Industry 4.0 is a realized reality, which already today has a growing application in medicine and dentistry. So, at this moment, its application is especially important in the fight against covid-19. Aim of the paper: The purpose of this review paper is to understand the role of Industry 4.0 in the field of medicine and dentistry and to identify research directions, including future applications, especially for covid-19. Material and method: A detailed analysis of papers on Industry 4.0 in medicine, dentistry and related fields was performed and possible applications and directions of research were identified, especially for covid-19.Result: Through this review study, we identified different technologies, opportunities and research status of Industry 4.0 in the field of medicine, dentistry and covid-19 pandemic, through 19 areas of application. We can say that Industry 4.0 will become an essential part of tomorrow's smart factory of medical and dental devices. Conclusion: Industry 4.0 shows a wide range of possibilities for the production of newly adapted implants (medical and dental) and innovative tools and instruments for the field of medicine and dentistry. This model enables the creation of a digital clinic and digital office, with a complete system of medical and dental monitoring, which meets the individual requirements of the patient, thus creating the industry of medicine and dentistry with optimization of treatment time and costs. In the future, Industry 4.0 will create new capabilities and innovative protocols for the treatment and care of patients, both in medicine and dentistry.