This study aims to empirically determine and analyze the role of women's participation in politics, female population growth, trade balance, and women's labor force participation in promoting economic development across 15 OIC countries during the 2006-2017 period, both in short- and long-run from an Islamic perspective. Using the Panel Autoregressive Distributed Lag (ARDL) method, this study found that, in the short term, trade balance and women's labor force participation have promoted Islamic economic development. In contrast, women's participation has a negative effect on the economic development of OIC countries. In the long term, on the other hand, all variables have promoted Islamic economic development in OIC countries, except for the trade balance variable. These findings suggest that coordination and synergy for strengthening economic development among OIC countries need to be enhanced, focusing on women's role in politics, labor force, quality of population, and economic dimensions.JEL Classification: C33, F16, J16, O11, P48Ramdayani, S., Majid, M. S. A., & Suriani, S. (2021). Does Women's Participation in Politics Matter for Economic Development in OIC-15? An Islamic Perspective. Signifikan: Jurnal Ilmu Ekonomi, 10 (2), 209-222. https://doi.org/10.15408/sjie.v10i2.20214.