Purpose: to conduct a comparative analysis of the indicators of the competitive activity of the strongest fighters of men and women of mixed martial arts MMA from the TOP-10, regardless of weight. Material and methods. The research used the following methods: analysis of scientific and methodological information and Internet sources; generalization of best practical experience; analysis of protocols and videos of the competitive activity of men and women fighters from the TOP-10, regardless of weight; methods of mathematical statistics. The performance output of the strongest male and female MMA fighters is taken from the UFC website. Results: the analysis of the strongest fighters of women and men from the TOP-10, regardless of weight, showed that the average age of women is 32,7±3,74 years, and of men – 33,2±2,75 years. The average fight time for women is 16,25±3,43 minutes, and for men – 12,76±3,05 minutes. The TOP-10 strongest female fighters, regardless of weight, include representatives of six countries (four fighters from the United States, two representatives from Brazil and one athlete each from Kyrgyzstan, China, and the Netherlands), and the TOP-10 strongest male fighters regardless of weight also includes representatives of six countries (four fighters from the USA, two representatives from Russia and one athlete each from France, Nigeria, Brazil, Australia). It was found that male fighters from the TOP-10, regardless of weight, during their sports careers won 204 fights and lost 17 fights. For female fighters, these results are worse – 151 wins and 35 losses. Conclusions. Comparative analysis of the indicators of the competitive activity of the strongest fighters of women and men from the TOP-10, regardless of weight, showed that fighters of women and men deliver the same number of punches per minute (4,52 punches), and women fighters miss more punches (3,36 punches) than male fighters (2,60 strokes). The greatest number of punches was carried out by women and men in a standing position (women – 66,9 %; men – 64,6 %), then on the ground (women – 19,0 %; men – 21,6 %) and in a clinch (women – 14,1 %; men – 13,8 %). The largest number of blows are in the head (women – 60,2 %; men – 68,4 %), then on the body (women – 20,9 %; men – 18,3 %) and on the legs (women – 18,9 %; men – 13,3 %). The strongest fighters, women and men, defend against takedowns more efficiently (women – 77,5 %; men – 81,6 %) than against punches (women – 56,8 %; men – 59,8 %). The number of takedown attempts in 15 minutes is greater (women – 1,53 times; men – 1,86 times) than performing a submission in 15 minutes (women – 0,55 times; men – 0,53 times). Keywords: competitive activity, mixed martial arts MMA, TOP-10, indicators, fighters, men, women.