The survey research was conducted to analyze the economics of production and marketing of major vegetables in Parsa district of Nepal from December 2019 to April 2020. Primary data for the household survey were collected using a semi-structured questionnaire from sixty sampled respondents, sixteen from Pokhariya municipality, and forty-four from Bahudarmai municipality. Secondary data were collected through scientific journals, articles, and publications from agricultural organizations, projects, and programs. Average area under vegetable cultivation was found 12.68 Kattha. Out of five major vegetables under study average cost of production per kattha was found highest for pointed gourd (Rs. 11551.50) lowest for okra production (Rs. 6071/kata). The majority of production cost was covered by labor cost (>40%). The average productivity of cauliflower, okra,brinjal, chilli, and pointed gourd was 27.3 Mt/ha,19 Mt/ha,16.67 Mt/ha, 27.52Mt/ha, and 25.83Mt/ha respectively. B:C ratio of all the vegetables under study was higher than three which implies that vegetable farming in the study area is profitable farm business. Producers-wholesalers-retailers-consumers was the most used marketing channel. Market margin of cauliflower, okra, brinjal, chilli and pointed gourd was Rs. 13/kg, Rs. 7.73/kg, Rs. 7.86/kg, Rs. 28.07/kg and Rs. 8.69/kg respectively. Index of severity was constructed to rank the problems in the production and marketing of vegetables. Analysis of the problems identified shows the need for proper storage facilities, training related to vegetable farming and insect pest management, and subsidies on regular basis, and mechanization and modernization of the farming system through the introduction of technological knowledge and modern farm practice.