New Composite Material: PLLA and Tricalcium Phosphate for Orthopaedic Applications-In Vitro and In Vivo Studies (Part 1)

2016 ◽  
pp. 173-180
Author(s):  
Jean Charles Le Huec ◽  
Antonio Faundez ◽  
Stephane Aunoble ◽  
Rachid Sadikki ◽  
Julien Rigal
Keyword(s):  
Composite Material ◽  
Tricalcium Phosphate ◽  
In Vivo Studies

scholarly journals The Effect of Stromal-Derived Factor 1α on Osteoinduction Properties of Porous β-Tricalcium Phosphate Bioceramics

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Fangchun Jin ◽  
Qixun Cai ◽  
Wei Wang ◽  
Xiaohui Fan ◽  
Xiao Lu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Tissue Repair ◽  
In Vivo Studies ◽  
New Bone Formation ◽  
Defect Model ◽  
Rabbit Bone ◽  
In Vitro Effects

β-Tricalcium phosphate (TCP) is a type of bioceramic material which is commonly used for hard tissue repair and famous of its remarkable biocompatibility and osteoconductivity with similar composition to natural bone. However, TCP lacks osteoindcutive properties. Stromal-derived factor 1α (SDF-1α) can promote bone regeneration with excellent osteoinduction effect. In this study, SDF-1α was loaded into TCP to investigate the in vitro effects of SDF-1α on the osteoinductive properties of TCP. In vitro studies showed that SDF-1α/TCP scaffold significantly stimulated the expression of osteopontin and osteocalcin. As to the in vivo studies, the rabbit bone defect model showed that SDF-1α stimulated more new bone formation. In conclusion, SDF-1α/TCP bioceramic scaffolds could further promote bone regeneration compared to pure TCP bioceramics.

Totally Biodegradable and Osteoconductive Composite Material Consisting of Polyhydroxybutyrate and Tricalcium Phosphate for Bone Tissue Repair

2008 ◽  
Vol 47-50 ◽  
pp. 1395-1398
Author(s):  
Ya Liu ◽  
Min Wang
Keyword(s):  
Composite Material ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Tissue Repair ◽  
Scanning Calorimetry ◽  
Electron Microscopic ◽  
In Vivo Experiments ◽  
Composite Production

Totally biodegradable and osteoconductive composite material consisting of polyhydroxybutyrate (PHB) and β-tricalcium phosphate (β-TCP) was manufactured for bone tissue repair. The composite production process was optimized with the help of differential scanning calorimetry (DSC) analyses. Thermogravimetric analyses (TGA) indicated that intended compositions for TCP/PHB composite could be achieved through this manufacturing route. Scanning electron microscopic (SEM) examinations revealed that TCP/PHB composite containing up to 40 vol.% of β-TCP had satisfactory distribution of micron-sized TCP particles in the composite. The good-quality composite will be further investigated in in vitro and in vivo experiments.

POLYMERIC COMPOSITE MATERIAL FOR BONE IMPLANTS WITH THE FEASIBILITY OF INTRAOPERATIVE FORM CORRECTION

2021 ◽  
Vol 1 (19) ◽  
pp. 31-32
Author(s):  
F.S. Senatov ◽  
N.V. Strukova ◽  
M.S. Krivozubov ◽  
M.S. Generalova ◽  
K.E. Nikitin ◽  
...  
Keyword(s):  
Composite Material ◽  
Mechanical Characteristics ◽  
Polymeric Composite ◽  
In Vivo Studies ◽  
Polymeric Composite Material ◽  
Bone Implants

A biomimetic composite material based on polylactide (PLA), polycaprolactone (PCL) and hydroxyapatite (HAP) with high biocompatibility and osteoconductive properties was developed. The structural and mechanical characteristics of the material were investigated and in vitro and in vivo studies were carried out.

In vitro and in vivo studies of new cationic Zn(II)‐benzonaphthoporphyrazines as photosensitizers for PDT

2001 ◽  
Vol 5 (8) ◽  
pp. 645-651
Author(s):  
M. Peeva ◽  
M. Shopova ◽  
U. Michelsen ◽  
D. Wöhrle ◽  
G. Petrov ◽  
...  
Keyword(s):  
In Vivo Studies

Effect of caffeine on theophyliine on cerebral blood flow response to brain activation: In vitro and in vivo studies

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S198-S198
Author(s):  
Joseph R Meno ◽  
Thien-son K Nguyen ◽  
Elise M Jensen ◽  
G Alexander West ◽  
Leonid Groysman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Activation ◽  
In Vivo Studies ◽  
Blood Flow Response ◽  
Flow Response

Effects of Unfractionated and Low Molecular Weight Heparins on Platelet Thromboxane Biosynthesis “In Vivo”

1994 ◽  
Vol 72 (06) ◽  
pp. 942-946 ◽  
Author(s):  
Raffaele Landolfi ◽  
Erica De Candia ◽  
Bianca Rocca ◽  
Giovanni Ciabattoni ◽  
Armando Antinori ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Unfractionated Heparin ◽  
Low Molecular Weight Heparin ◽  
Primary Source ◽  
In Vivo Studies ◽  
Low Molecular Weight ◽  
Heparin Administration ◽  
To Receive

SummarySeveral “in vitro” and “in vivo” studies indicate that heparin administration may affect platelet function. In this study we investigated the effects of prophylactic heparin on thromboxane (Tx)A2 biosynthesis “in vivo”, as assessed by the urinary excretion of major enzymatic metabolites 11-dehydro-TxB2 and 2,3-dinor-TxB2. Twenty-four patients who were candidates for cholecystectomy because of uncomplicated lithiasis were randomly assigned to receive placebo, unfractionated heparin, low molecular weight heparin or unfractionaed heparin plus 100 mg aspirin. Measurements of daily excretion of Tx metabolites were performed before and during the treatment. In the groups assigned to placebo and to low molecular weight heparin there was no statistically significant modification of Tx metabolite excretion while patients receiving unfractionated heparin had a significant increase of both metabolites (11-dehydro-TxB2: 3844 ± 1388 vs 2092 ±777, p <0.05; 2,3-dinor-TxB2: 2737 ± 808 vs 1535 ± 771 pg/mg creatinine, p <0.05). In patients randomized to receive low-dose aspirin plus unfractionated heparin the excretion of the two metabolites was largely suppressed thus suggesting that platelets are the primary source of enhanced thromboxane biosynthesis associated with heparin administration. These data indicate that unfractionated heparin causes platelet activation “in vivo” and suggest that the use of low molecular weight heparin may avoid this complication.

Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies

2020 ◽  
Vol 72 (5) ◽  
Author(s):  
Mario Fadin ◽  
Maria C. Nicoletti ◽  
Marzia Pellizzato ◽  
Manuela Accardi ◽  
Maria G. Baietti ◽  
...  
Keyword(s):  
In Vivo Studies
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