Microencapsulation of basil essential oil: utilization of gum arabic/whey protein isolate/maltodextrin combinations for encapsulation efficiency and in vitro release

2021 ◽  
Author(s):  
Necla Ozdemir ◽  
Ali Bayrak ◽  
Tuba Tat ◽  
Filiz Altay ◽  
Mustafa Kiralan ◽  
...  
Keyword(s):  
Essential Oil ◽  
Whey Protein ◽  
Encapsulation Efficiency ◽  
In Vitro Release ◽  
Gum Arabic ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Oil Utilization ◽  
Vitro Release

Effect of the cross-linking agent and drying method on encapsulation efficiency of orange essential oil by complex coacervation using whey protein isolate with different polysaccharides

2018 ◽  
Vol 35 (2) ◽  
pp. 165-180 ◽  
Author(s):  
Sandra Rojas-Moreno ◽  
Guillermo Osorio-Revilla ◽  
Tzayhrí Gallardo-Velázquez ◽  
Fernando Cárdenas-Bailón ◽  
Gabriela Meza-Márquez
Keyword(s):  
Essential Oil ◽  
Whey Protein ◽  
Encapsulation Efficiency ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Cross Linking ◽  
Complex Coacervation ◽  
Drying Method ◽  
The Cross ◽  
Orange Essential Oil

scholarly journals Impact of Gelatin Supplemented with Gum Arabic, Tween 20, and β-Cyclodextrin on the Microencapsulation of Turkish Oregano Extract

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 176 ◽  
Author(s):  
Juste Baranauskaite ◽  
Dalia M. Kopustinskiene ◽  
Jurga Bernatoniene
Keyword(s):  
Rosmarinic Acid ◽  
Encapsulation Efficiency ◽  
In Vitro Release ◽  
Gum Arabic ◽  
Product Yield ◽  
Wall Material ◽  
Tween 20 ◽  
Active Compounds ◽  
Vitro Release

Microencapsulation protects core materials from deteriorating due to environmental conditions, such as moisture or oxidation, and improves the bioavailability of active compounds, allowing one to make solid formulations from oils and increase their solubility. Wall and core material properties determine the microencapsulation efficiency and the best results are achieved when a wall material mixture is used to prepare the microcapsules. In this work, we optimized the wall material composition (gelatin supplemented with gum Arabic, Tween 20, and β-cyclodextrin) of Turkish oregano microcapsules prepared by spray-drying technology to increase the product yield, the encapsulation efficiency, and to achieve narrower particle size distribution. When the wall material solution contained 10 g of gelatin, 7.5 g of gum Arabic, 1.99 g of Tween 20, 1.98 g of β-cyclodextrin, and 20 g of ethanolic oregano extract, the encapsulation efficiency of oregano’s active compounds, rosmarinic acid and carvacrol, were 96.7% and 99.8%, respectively, and the product yield was 85.63%. The physicochemical properties, microscopic morphology, and in vitro release of the prepared microcapsules were characterized in the study. The use of gelatin as the main coating material, in supplementation with gum Arabic, Tween 20, and β-cyclodextrin, not only improved the encapsulation efficiency, but also increased the in vitro release of both main active compounds of Turkish oregano extract—rosmarinic acid and carvacrol.

Study of the Encapsulation Efficiency and Controlled Release Property of Whey Protein Isolate--Polysaccharide Complexes in W1/O/W2 Double Emulsions

2011 ◽  
Vol 7 (3) ◽  
Author(s):  
Bin Li ◽  
Yanfeng Jiang ◽  
Fei Liu ◽  
Zhi Chai ◽  
Yuanyuan Li ◽  
...  
Keyword(s):  
Controlled Release ◽  
Whey Protein ◽  
Encapsulation Efficiency ◽  
Guar Gum ◽  
Gum Arabic ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Water Soluble ◽  
Double Emulsions ◽  
Water Soluble Vitamin

The complexes of whey protein isolate (WPI) with guar gum (GG) or gum arabic (GA) were used to prepare water-oil-water double emulsions. Lipid-soluble vitamin E (VE) and water-soluble vitamin B2 (VB2) were encapsulated together in these two systems. The abilities of these complexes to control the release rates were compared. When the ratio of WPI/polysaccharides increased from 5:0.1 to 5:0.5, the encapsulation efficiency (EE) of VE increased from 73 to 88 percent, and EEVB2 from 61 to 68 percent in WPI-GG system; whereas only minor changes were in both EEVE and EEVB2 in WPI-GA system. In the controlled release study, WPI-GG complexes showed better resistance to the attack of the enzymes than WPI-GA complexes did. These phenomena were attributed to the formation of compact aggregates promoted by electrostatic effects.

Thyme essential oil loaded in nanocochleates: Encapsulation efficiency, in vitro release study and antioxidant activity

LWT ◽  
2017 ◽  
Vol 77 ◽  
pp. 497-502 ◽  
Author(s):  
Martina Asprea ◽  
Isabella Leto ◽  
Maria Camilla Bergonzi ◽  
Anna Rita Bilia
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Encapsulation Efficiency ◽  
In Vitro Release ◽  
Thyme Essential Oil ◽  
Release Study ◽  
Vitro Release

Optimization and Characterization of Aqueous Micellar Formulations for Ocular Delivery of an Antifungal Drug, Posaconazole

2020 ◽  
Vol 26 (14) ◽  
pp. 1543-1555 ◽  
Author(s):  
Meltem E. Durgun ◽  
Emine Kahraman ◽  
Sevgi Güngör ◽  
Yıldız Özsoy
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Size Distribution ◽  
Encapsulation Efficiency ◽  
Fungal Infections ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
Glycol Succinate ◽  
Vitro Release

Background: Topical therapy is preferred for the management of ocular fungal infections due to its superiorities which include overcoming potential systemic side effects risk of drugs, and targeting of drugs to the site of disease. However, the optimization of effective ocular formulations has always been a major challenge due to restrictions of ocular barriers and physiological conditions. Posaconazole, an antifungal and highly lipophilic agent with broad-spectrum, has been used topically as off-label in the treatment of ocular fungal infections due to its highly lipophilic character. Micellar carriers have the potential to improve the solubility of lipophilic drugs and, overcome ocular barriers. Objective: In the current study, it was aimed optimization of posaconazole loaded micellar formulations to improve aqueous solubility of posaconazole and to characterize the formulations and to investigate the physical stability of these formulations at room temperature (25°C, 60% RH), and accelerated stability (40°C, 75% RH) conditions. Method: Micelles were prepared using a thin-film hydration method. Pre-formulation studies were firstly performed to optimize polymer/surfactant type and to determine their concentration in the formulations. Then, particle size, size distribution, and zeta potential of the micellar formulations were measured by ZetaSizer Nano-ZS. The drug encapsulation efficiency of the micelles was quantified by HPLC. The morphology of the micelles was depicted by AFM. The stability of optimized micelles was evaluated in terms of particle size, size distribution, zeta potential, drug amount and pH for 180 days. In vitro release studies were performed using Franz diffusion cells. Results: Pre-formulation studies indicated that single D-ɑ-tocopheryl polyethylene glycol succinate (TPGS), a combination of it and Pluronic F127/Pluronic F68 are capable of formation of posaconazole loaded micelles at specific concentrations. Optimized micelles with high encapsulation efficiency were less than 20 nm, approximately neutral, stable, and in aspherical shape. Additionally, in vitro release data showed that the release of posaconazole from the micelles was higher than that of suspension. Conclusion: The results revealed that the optimized micellar formulation of posaconazole offers a potential approach for topical ocular administration.

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