scholarly journals Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

2011 ◽  
Vol 22 (10) ◽  
pp. 2048-2059 ◽  
Author(s):  
Brian M. Zeglis ◽  
Priya Mohindra ◽  
Gabriel I. Weissmann ◽  
Vadim Divilov ◽  
Scott A. Hilderbrand ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Click Chemistry ◽  
Diels Alder ◽  
Emission Tomography ◽  
Inverse Electron Demand ◽  
Positron Emission ◽  
Electron Demand

Enabling [18F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [18F]-anti-microRNA-21 as an example

2015 ◽  
Vol 51 (48) ◽  
pp. 9821-9824 ◽  
Author(s):  
Xiang-Guo Li ◽  
Anne Roivainen ◽  
Jörgen Bergman ◽  
Arttu Heinonen ◽  
Frank Bengel ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Diels Alder ◽  
Emission Tomography ◽  
Inverse Electron Demand ◽  
Positron Emission ◽  
Electron Demand

Bicyclo[6.1.0]nonyne (BCN)-based inverse electron demand Diels–Alder (IEDDA) conjugation for 18F-labeling of oligonucleotides!

scholarly journals A click chemistry-based microRNA maturation assay optimized for high-throughput screening

2016 ◽  
Vol 52 (53) ◽  
pp. 8267-8270 ◽  
Author(s):  
Daniel A. Lorenz ◽  
Amanda L. Garner
Keyword(s):  
Click Chemistry ◽  
High Throughput ◽  
High Throughput Screening ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Electron Demand

A catalytic enzyme-linked click chemistry assay (cat-ELCCA) for Dicer-catalyzed pre-microRNA maturation was optimized to employ inverse-electron demand Diels–Alder (IEDDA) chemistry affording high-throughput screening capability.

scholarly journals Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels-Alder Click Chemistry

ChemistryOpen ◽  
2017 ◽  
Vol 6 (5) ◽  
pp. 615-619 ◽  
Author(s):  
Christian Brand ◽  
Pasquale Iacono ◽  
Carlos Pérez-Medina ◽  
Willem J. M. Mulder ◽  
Moritz F. Kircher ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Specific Binding ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Liposomal Nanoparticles ◽  
Electron Demand

scholarly journals A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates

2019 ◽  
Author(s):  
Mathis Baalmann ◽  
Laura Neises ◽  
Sebastian Bitsch ◽  
Hendrik Schneider ◽  
Lukas Deweid ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Protein Level ◽  
Product Formation ◽  
Diels Alder ◽  
Side Product ◽  
Efficient Technology ◽  
Inverse Electron Demand ◽  
Protein Conjugates ◽  
Scientific Disciplines ◽  
Electron Demand

A highly efficient technology for protein functionalization with commonly used bioorthogonal motifs for Diels-Alder cycloaddition with inverse electron demand (DA<sub>inv</sub>). With the aim of precisely generating branched protein chimeras, we systematically assessed the reactivity, stability and side product formation of various bioorthogonal chemistries directly at the protein level. We demonstrate the efficiency and versatility of our conjugation platform using different functional proteins and the therapeutic antibody trastuzumab. This technology enables fast and routine access to tailored and hitherto inaccessible protein chimeras useful for a variety of scientific disciplines.

scholarly journals Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry

2016 ◽  
Vol 16 (1) ◽  
pp. 124-133 ◽  
Author(s):  
Jacob L. Houghton ◽  
Rosemery Membreno ◽  
Dalya Abdel-Atti ◽  
Kristen M. Cunanan ◽  
Sean Carlin ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Diels Alder ◽  
In Vivo Efficacy ◽  
Inverse Electron Demand ◽  
Pretargeted Radioimmunotherapy ◽  
Electron Demand

scholarly journals A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles

2021 ◽  
Author(s):  
Jin Teh ◽  
Marta Costa-Braga ◽  
Louis Allott ◽  
Chris Barnes ◽  
Javier Hernandez-Gil ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Radiochemical Yield ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Electron Demand ◽  
18F Fluoride

The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield...

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