Interactions of Schiff base compounds and their coordination complexes with the drug cisplatin

The coordination complexes of Co(II) and Zn(II) with Schiff bases derived from o-phenylenediamine and substituted 2-hydroxybenzaldehyde were prepared All compounds were characterized by Fourier transform infrared (FTIR) spectroscopy and Nuclear magnetic resonance (NMR) spectroscopy elemental analyzers. They were analyzed using impedance spectroscopy in the frequency range of 100Hz-1 MHz. LI and L2 showed higher conductivity compared to their metal complexes, which had values of 1.3 7 x 10-7 and 6.13 x 10-8 S/cm respectively.

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4-vinylpyridine derivatives: Protonation, methylation and silver(I) coordination chemistry

Journal of Chemical Research ◽

10.1177/1747519821989659 ◽

2021 ◽

pp. 174751982198965

Author(s):

Guoqi Zhang

Keyword(s):

Mass Spectrometry ◽

Schiff Base ◽

Coordination Chemistry ◽

Elemental Analysis ◽

Silver Complex ◽

Spectroscopic Techniques ◽

X Ray ◽

X Ray Crystallography ◽

Pyridine Moiety ◽

New Compounds

( E)-4-[2-(Pyridin-4-yl)vinyl]benzaldehyde, containing both a 4-vinylpyridine and an aldehyde functionality, is utilized to develop new, highly conjugated chalcone compounds and a bis-Schiff base azine compound. The chalcone-containing compounds are further explored for their protonation, methylation and silver(I) coordination chemistry using the pyridine moiety. In parallel, a cyano-containing analogue, ( E)-4-[2-(pyridin-4-yl)vinyl]benzonitrile is also synthesized and studied for its silver(I) coordination chemistry. These new compounds are fully characterized by mass spectrometry, elemental analysis and spectroscopic techniques. The methylated product of ( E)-1-(9-anthryl)-3-{4-[2-(pyridin-4-yl)vinyl]phenyl}prop-2-en-1-one and a silver complex of ( E)-4-[2-(pyridin-4-yl)vinyl]benzonitrile are structurally determined by X-ray crystallography.

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Core-modified porphyrins: novel building blocks in chemistry

Physical Sciences Reviews ◽

10.1515/psr-2021-0079 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Aleksey E. Kuznetsov

Keyword(s):

Periodic Table ◽

Building Blocks ◽

Effective Strategy ◽

Research Groups ◽

Structures And Properties ◽

Porphyrin Core ◽

Living Organisms ◽

New Compounds ◽

Related Compounds ◽

Nitrogen Phosphorus

Abstract Various (metallo)porphyrins and related compounds have been intensively investigated by different research groups due to their extremely important role in living organisms along with their versatile applications in technology. The design of novel porphyrinoids by core-modification, or substitution of pyrrole nitrogens, with the elements of other groups of the Periodic Table has been considered as a highly promising methodology for tuning structures and properties of porphyrinoids and thus opening new possible applications for them. Much effort has been given to the modifications of the porphyrin core with elements of the main groups, namely O, S, Se (chalcogens), and the heavier congener of nitrogen, phosphorus. In general, the porphyrin core modification by replacing nitrogens with heteroatoms is a promising and effective strategy for obtaining new compounds with unusual structures and properties (optical, electrochemical, coordinating, etc.) as well as reactivity. These novel molecules can also be employed as promising building or construction blocks in various applications in the nanotechnology area.

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Synthesis, characterization, in silico analysis and physicochemical properties of tin(II) and lead(II) coordination complexes prepared using 2-((3,5-dimethoxybenzylidene)amino)pyridin-3-ol and 1,10-phenanthroline

Polyhedron ◽

10.1016/j.poly.2018.10.037 ◽

2019 ◽

Vol 157 ◽

pp. 536-547 ◽

Cited By ~ 1

Author(s):

Kollur Shiva Prasad ◽

Govindaraju Shruthi ◽

Chandan Shivamallu

Keyword(s):

Physicochemical Properties ◽

In Silico ◽

In Silico Analysis ◽

Coordination Complexes ◽

Silico Analysis

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Thermal and long period stability of series of V(V), V(IV) and V(III) complex with Schiff base ligands in solid state

Science Technology and Innovation ◽

10.5604/01.3001.0013.1547 ◽

2019 ◽

Vol 4 (1) ◽

pp. 30-36 ◽

Cited By ~ 1

Author(s):

Janusz Szklarzewicz ◽

Anna Jurowska ◽

Maciej Hodorowicz ◽

Ryszard Gryboś

Keyword(s):

Thermal Stability ◽

Schiff Base ◽

Solid State ◽

Physicochemical Properties ◽

General Formula ◽

Oxidation State ◽

Magnetic Moment ◽

Tridentate Ligand ◽

Schiff Base Ligands ◽

Long Period

The synthesis and physicochemical properties of three new complexes of vanadium at +5, +4 and +3 oxidation state are described and discussed. The octahedral surrounding of vanadium for V(III) complexes of [V(L1)(HL1)] general formula is filled with two ONO tridentate ligand L, for V(IV) one ONO ligand L, oxido ligand and 1,10-phenanthroline (phen) as a co-ligand are presented in complexes of [VO(L2)(phen)]. For V(V) the complexes of [VO2(L1)(solv)] type were formed. As ligands, the H2L Schiff bases were formed in reaction between 5-hydroxysalcylaldehyde and phenylacetic hydrazide (H2L1) and 3,5-dichlorosalicyaldehyde and 4-hydroxybenzhydrazide (L2). The magnetic moment measurements, in 8 year period, show, that V(III) complexes slowly oxidise to V(IV) with preservation of the nonoxido character of the complexes, while V(IV) complexes were found to be stable. The TG and SDTA measurements indicate, that thermal stability depends mainly on the oxidation state of vanadium. The less thermally stable are the V(V) complexes, while V(IV) and V(III) are stable up to ca. 200oC. In solution, at pH 2 (similar to that in human digestion system), again the V(IV) are the most stable, only at pH 7.0 V(III) complexes had higher stability. The most stable, thus best for pharmaceutical use, are V(IV) complexes.

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Synthesis, Characterization and Biological Activity Study of New Compounds Tetrazole Derivatives Azo-Schiff Base

journal of the college of basic education ◽

10.35950/cbej.v25i103.4547 ◽

2019 ◽

Vol 25 (103) ◽

pp. 68-89

Author(s):

Hiba Ibrahim Abdulla AL-Joubory ◽

Khalid Mohamad Motny Al-janaby

Keyword(s):

Biological Activity ◽

Schiff Base ◽

Pathogenic Bacteria ◽

Diazonium Salt ◽

Aldehyde Group ◽

Spectroscopic Techniques ◽

Phenyl Hydrazine ◽

Ft Ir ◽

New Compounds ◽

Tetrazole Derivatives

This work included synthesis of azo dye (H1) by the reaction of diazonium salt to sulfacetamide with 4-hydroxy benzaldehyde at (0-5) oC and synthesis of schiff base (H2-H6) through reaction substituted aromatic amine (aniline, 4-nitro aniline, 4-chloro aniline, 4-amino benzoic acid and phenyl hydrazine) with aldehyde group in azo compound (H1) in ethanol compounds (H2-H6) and tetrazole derivatives prepared by reaction schiff base with sodium azide in ethanol compounds (H7-H11) and characterization by using spectroscopic techniques Uv/Vis, FT-IR, C.H.N. and H1-NMR of some the prepared compounds using DMSO-d6 a solvent, in addition melting point and determination a purity of TLC, and this work consists a study of biological activity for the some prepared compounds against four types of pathogenic bacteria and know to be resistant to anti biotic.

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Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde

European Journal of Chemistry ◽

10.5155/eurjchem.10.1.26-29.1790 ◽

2019 ◽

Vol 10 (1) ◽

pp. 26-29

Author(s):

Ibtihal Hassan Hatim ◽

Wasfi Aboud Al-Masoudi ◽

Rashad Fadhil Ghadhban

Keyword(s):

Body Weight ◽

Schiff Base ◽

Nmr Spectroscopy ◽

Acute Toxicity ◽

Elemental Analysis ◽

Good Yield ◽

Mice Model ◽

Base Derivative ◽

New Compounds

There is an urgent need for the design and development of new and safer drugs, this has attracted organic chemists to synthesize new compounds with potential of biological and chemotherapeutic activities. Here we report, the condensation of phenylethylamine with 2-hydroxy naphthaldehyde yielded Schiff base derivative in good yield. Characterization of synthesized compound was carried by elemental analysis, IR, 1H-, 13C- and HSQC-NMR spectroscopy. The toxicity of the synthesized compound was determined using Balb/c mice model. Dixon’s up and down method was found to have an LD50 of 827.2 mg/kg of body weight, moderate toxicity.

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Synthesis of cis, cis-1,3,5-trisubstituted cyclohexane based chelators with polyfunctional pendant arms

Journal of Chemical Research ◽

10.3184/0308234053431149 ◽

2005 ◽

Vol 2005 (1) ◽

pp. 43-45 ◽

Cited By ~ 3

Author(s):

Minati Baral ◽

B.K. Kanungo ◽

Peter Moore

Keyword(s):

Schiff Base ◽

Nmr Spectroscopy ◽

Organic Compounds ◽

Elemental Analysis ◽

H Nmr ◽

Benzenetricarboxylic Acid ◽

New Compounds ◽

Pendant Arms ◽

C Nmr

Some novel organic compounds of the type: cis, cis-1,3,5-tris(X)cyclohexane, where X= –CONH(CH2)2NH2, –CONH(CH2)3NH2, –CONH(CH2)2NCH –C6H4OH, CONH(CH2)3NCHC6H4OH, which are expected to function as potential polydentate chelators have been synthesised from 1,3,5-benzenetricarboxylic acid through multi-steps reactions. 1,3,5-benzenetricarboxylic acid was reduced to cis, cis-1,3,5-tris(ethylcarboxylate)cyclohexane, which on reaction with excess of 1,2-diaminoethane and 1,2-diaminopropane afforded two new compounds. Condensation of the obtained derivatives with three equivalents of salicylaldehyde resulted the formation of two new Schiff base compounds. All the compounds were characterised by a combination of elemental analysis, mass, IR, UV-Vis, 1H NMR and 13C NMR spectroscopy.

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