scholarly journals Dynamics Analysis and Simulation of a Modified HIV Infection Model with a Saturated Infection Rate

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Qilin Sun ◽  
Lequan Min
Keyword(s):  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Equilibrium Point ◽  
Infection Rate ◽  
Reproductive Number ◽  
Infection Model ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Hiv Rna

This paper studies a modified human immunodeficiency virus (HIV) infection differential equation model with a saturated infection rate. It is proved that if the basic virus reproductive numberR0of the model is less than one, then the infection-free equilibrium point of the model is globally asymptotically stable; ifR0of the model is more than one, then the endemic infection equilibrium point of the model is globally asymptotically stable. Based on the clinical data from HIV drug resistance database of Stanford University, using the proposed model simulates the dynamics of the two groups of patients’ anti-HIV infection treatment. The numerical simulation results are in agreement with the evolutions of the patients’ HIV RNA levels. It can be assumed that if an HIV infected individual’s basic virus reproductive numberR0<1then this person will recover automatically; if an antiretroviral therapy makes an HIV infected individual’sR0<1, this person will be cured eventually; if an antiretroviral therapy fails to suppress an HIV infected individual’s HIV RNA load to be of unpredictable level, the time that the patient’s HIV RNA level has achieved the minimum value may be the starting time that drug resistance has appeared.

scholarly journals Threshold dynamics and threshold analysis of HIV infection model with treatment

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Zhimin Chen ◽  
Xiuxiang Liu ◽  
Liling Zeng
Keyword(s):  
Hiv Infection ◽  
Time Delays ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Threshold Dynamics ◽  
Positive Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Immunodeficiency Virus ◽  
Hiv Infection Model

Abstract In this paper, a human immunodeficiency virus (HIV) infection model that includes a protease inhibitor (PI), two intracellular delays, and a general incidence function is derived from biologically natural assumptions. The global dynamical behavior of the model in terms of the basic reproduction number $\mathcal{R}_{0}$ R 0 is investigated by the methods of Lyapunov functional and limiting system. The infection-free equilibrium is globally asymptotically stable if $\mathcal{R}_{0}\leq 1$ R 0 ≤ 1 . If $\mathcal{R}_{0}>1$ R 0 > 1 , then the positive equilibrium is globally asymptotically stable. Finally, numerical simulations are performed to illustrate the main results and to analyze thre effects of time delays and the efficacy of the PI on $\mathcal{R}_{0}$ R 0 .

scholarly journals Global Dynamics of an HIV Infection Model with Two Classes of Target Cells and Distributed Delays

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
A. M. Elaiw
Keyword(s):  
T Cells ◽  
Steady State ◽  
Hiv Infection ◽  
Infection Model ◽  
Target Cells ◽  
Global Dynamics ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Hiv Infection Model ◽  
Nonlinear Delay

We investigate the global dynamics of an HIV infection model with two classes of target cells and multiple distributed intracellular delays. The model is a 5-dimensional nonlinear delay ODEs that describes the interaction of the HIV with two classes of target cells, CD4+T cells and macrophages. The incidence rate of infection is given by saturation functional response. The model has two types of distributed time delays describing time needed for infection of target cell and virus replication. This model can be seen as a generalization of several models given in the literature describing the interaction of the HIV with one class of target cells, CD4+T cells. Lyapunov functionals are constructed to establish the global asymptotic stability of the uninfected and infected steady states of the model. We have proven that if the basic reproduction numberR0is less than unity then the uninfected steady state is globally asymptotically stable, and ifR0>1then the infected steady state exists and it is globally asymptotically stable.

Global Stability of a HBV Infection Model with Saturated Infection Rates and Time Delay

2013 ◽  
Vol 791-793 ◽  
pp. 1314-1317
Author(s):  
Wei Juan Pang ◽  
Zhi Xing Hu ◽  
Fu Cheng Liao
Keyword(s):  
Global Stability ◽  
Sufficient Conditions ◽  
Hbv Infection ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Infection Model ◽  
Asymptotically Stable ◽  
Infection Rates ◽  
Globally Asymptotically Stable ◽  
Viral Infection Model

This paper investigates the global stability of a viral infection model of HBV infection of hepatocytes with saturated infection rate and intracellular delay. we obtain if the basic reproductive number is less than or equal to one, the infection-free equilibrium is globally asymptotically stable. If its greater than one, we obtain the sufficient conditions for the global stability of the infected equilibrium.

scholarly journals Stability Analysis of an HIV/AIDS Dynamics Model with Drug Resistance

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Qianqian Li ◽  
Shengshan Cao ◽  
Xiao Chen ◽  
Guiquan Sun ◽  
Yunxi Liu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Threshold Value ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Asymptotically Stable ◽  
Dynamics Model ◽  
Globally Asymptotically Stable ◽  
Antiretroviral Drug ◽  
Disease Free ◽  
Hiv Aids

A mathematical model of HIV/AIDS transmission incorporating treatment and drug resistance was built in this study. We firstly calculated the threshold value of the basic reproductive number (R0) by the next generation matrix and then analyzed stability of two equilibriums by constructing Lyapunov function. WhenR0<1, the system was globally asymptotically stable and converged to the disease-free equilibrium. Otherwise, the system had a unique endemic equilibrium which was also globally asymptotically stable. While an antiretroviral drug tried to reduce the infection rate and prolong the patients’ survival, drug resistance was neutralizing the effects of treatment in fact.

Stability and Hopf bifurcation of a delayed virus infection model with latently infected cells and Beddington–DeAngelis incidence

2020 ◽  
Vol 13 (05) ◽  
pp. 2050045
Author(s):  
Junxian Yang ◽  
Shoudong Bi
Keyword(s):  
Immune Response ◽  
Hopf Bifurcation ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Infection Model ◽  
Asymptotically Stable ◽  
Response Delay ◽  
Globally Asymptotically Stable ◽  
Latently Infected ◽  
Infected Cells

In this paper, the dynamical behaviors for a five-dimensional virus infection model with Latently Infected Cells and Beddington–DeAngelis incidence are investigated. In the model, four delays which denote the latently infected delay, the intracellular delay, virus production period and CTL response delay are considered. We define the basic reproductive number and the CTL immune reproductive number. By using Lyapunov functionals, LaSalle’s invariance principle and linearization method, the threshold conditions on the stability of each equilibrium are established. It is proved that when the basic reproductive number is less than or equal to unity, the infection-free equilibrium is globally asymptotically stable; when the CTL immune reproductive number is less than or equal to unity and the basic reproductive number is greater than unity, the immune-free infection equilibrium is globally asymptotically stable; when the CTL immune reproductive number is greater than unity and immune response delay is equal to zero, the immune infection equilibrium is globally asymptotically stable. The results show that immune response delay may destabilize the steady state of infection and lead to Hopf bifurcation. The existence of the Hopf bifurcation is discussed by using immune response delay as a bifurcation parameter. Numerical simulations are carried out to justify the analytical results.

scholarly journals Global stability analysis of a delayed HIV model with saturated infection rate

2018 ◽  
Vol 241 ◽  
pp. 01007
Author(s):  
jaouad Danane ◽  
Karam Allali
Keyword(s):  
Global Stability ◽  
Equilibrium Point ◽  
Infection Rate ◽  
Asymptotically Stable ◽  
Delay Model ◽  
Globally Asymptotically Stable ◽  
Hiv Model ◽  
Global Properties ◽  
Discrete Delays ◽  
Infected Cells

In this paper, the global stability of a delayed HIV model with saturated infection rate infection is investigated. We incorporate two discrete delays into the model; the first describes the intracellular delay in the production of the infected cells, while the second describes the needed time for virions production. We also derive the global properties of this two-delay model as function of the basic reproduction number R0. By using some suitable Lyapunov functions, it is proved that the free-equilibrium point is globally asymptotically stable when R0 ≤ 1, and the endemic equilibrium point is globally asymptotically stable when R0 ≥ 1. Finally, in order to support our theoretical findings we have illustrate some numerical simulations.

Dynamics of a Delayed HIV-1 Infection Model with Saturation Incidence Rate and CTL Immune Response

2016 ◽  
Vol 26 (14) ◽  
pp. 1650234 ◽  
Author(s):  
Ting Guo ◽  
Haihong Liu ◽  
Chenglin Xu ◽  
Fang Yan
Keyword(s):  
Immune Response ◽  
Equilibrium Point ◽  
Incidence Rate ◽  
Virus Production ◽  
Infection Model ◽  
Asymptotically Stable ◽  
Equilibrium Solutions ◽  
Globally Asymptotically Stable ◽  
Ctl Immune Response ◽  
Response Formula

In this paper, we investigate the dynamics of a five-dimensional virus model incorporating saturation incidence rate, CTL immune response and three time delays which represent the latent period, virus production period and immune response delay, respectively. We begin this model by proving the positivity and boundedness of the solutions. Our model admits three possible equilibrium solutions, namely the infection-free equilibrium [Formula: see text], the infectious equilibrium without immune response [Formula: see text] and the infectious equilibrium with immune response [Formula: see text]. Moreover, by analyzing corresponding characteristic equations, the local stability of each of the feasible equilibria and the existence of Hopf bifurcation at the equilibrium point [Formula: see text] are established, respectively. Further, by using fluctuation lemma and suitable Lyapunov functionals, it is shown that [Formula: see text] is globally asymptotically stable when the basic reproductive numbers for viral infection [Formula: see text] is less than unity. When the basic reproductive numbers for immune response [Formula: see text] is less than unity and [Formula: see text] is greater than unity, the equilibrium point [Formula: see text] is globally asymptotically stable. Finally, some numerical simulations are carried out for illustrating the theoretical results.

scholarly journals Dynamics Analysis of an HIV Infection Model including Infected Cells in an Eclipse Stage

2013 ◽  
Vol 2013 ◽  
pp. 1-12
Author(s):  
Shengyu Zhou ◽  
Zhixing Hu ◽  
Wanbiao Ma ◽  
Fucheng Liao
Keyword(s):  
Hiv Infection ◽  
The Body ◽  
Infection Model ◽  
Hopf Bifurcations ◽  
Asymptotically Stable ◽  
Ode Model ◽  
Response Delay ◽  
Globally Asymptotically Stable ◽  
Infected Cells ◽  
Hiv Infection Model

In this paper, an HIV infection model including an eclipse stage of infected cells is considered. Some quicker cells in this stage become productively infected cells, a portion of these cells are reverted to the uninfected class, and others will be latent down in the body. We consider CTL-response delay in this model and analyze the effect of time delay on stability of equilibrium. It is shown that the uninfected equilibrium and CTL-absent infection equilibrium are globally asymptotically stable for both ODE and DDE model. And we get the global stability of the CTL-present equilibrium for ODE model. For DDE model, we have proved that the CTL-present equilibrium is locally asymptotically stable in a range of delays and also have studied the existence of Hopf bifurcations at the CTL-present equilibrium. Numerical simulations are carried out to support our main results.

scholarly journals Viral Dynamics of Acute HIV-1 Infection

1999 ◽  
Vol 190 (6) ◽  
pp. 841-850 ◽  
Author(s):  
Susan J. Little ◽  
Angela R. McLean ◽  
Celsa A. Spina ◽  
Douglas D. Richman ◽  
Diane V. Havlir
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Doubling Time ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Target Cells ◽  
Viral Dynamics ◽  
Acute Hiv Infection ◽  
Acute Hiv ◽  
The Mean

Viral dynamics were intensively investigated in eight patients with acute HIV infection to define the earliest rates of change in plasma HIV RNA before and after the start of antiretroviral therapy. We report the first estimates of the basic reproductive number (R0), the number of cells infected by the progeny of an infected cell during its lifetime when target cells are not depleted. The mean initial viral doubling time was 10 h, and the peak of viremia occurred 21 d after reported HIV exposure. The spontaneous rate of decline (α) was highly variable among individuals. The phase 1 viral decay rate (δI = 0.3/day) in subjects initiating potent antiretroviral therapy during acute HIV infection was similar to estimates from treated subjects with chronic HIV infection. The doubling time in two subjects who discontinued antiretroviral therapy was almost five times slower than during acute infection. The mean basic reproductive number (R0) of 19.3 during the logarithmic growth phase of primary HIV infection suggested that a vaccine or postexposure prophylaxis of at least 95% efficacy would be needed to extinguish productive viral infection in the absence of drug resistance or viral latency. These measurements provide a basis for comparison of vaccine and other strategies and support the validity of the simian immunodeficiency virus macaque model of acute HIV infection.

Stability of a CD4+ T cell viral infection model with diffusion

2018 ◽  
Vol 11 (05) ◽  
pp. 1850071 ◽  
Author(s):  
Zhiting Xu ◽  
Youqing Xu
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Lyapunov Functions ◽  
Threshold Value ◽  
Endemic Equilibrium ◽  
Infection Model ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
The Stability ◽  
Viral Infection Model

This paper is devoted to the study of the stability of a CD[Formula: see text] T cell viral infection model with diffusion. First, we discuss the well-posedness of the model and the existence of endemic equilibrium. Second, by analyzing the roots of the characteristic equation, we establish the local stability of the virus-free equilibrium. Furthermore, by constructing suitable Lyapunov functions, we show that the virus-free equilibrium is globally asymptotically stable if the threshold value [Formula: see text]; the endemic equilibrium is globally asymptotically stable if [Formula: see text] and [Formula: see text]. Finally, we give an application and numerical simulations to illustrate the main results.

Sign in / Sign up

Export Citation Format

Share Document