scholarly journals Condition for Global Stability for a SEIR Model Incorporating Exogenous Reinfection and Primary Infection Mechanisms

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Isaac Mwangi Wangari
Keyword(s):  
Global Stability ◽  
Geometric Approach ◽  
Globally Asymptotically Stable ◽  
Seir Model ◽  
Effective Contact ◽  
Background Mortality ◽  
Infection Mechanisms ◽  
Infection Processes ◽  
Exogenous Reinfection ◽  
Bendixson Criterion

A mathematical model incorporating exogenous reinfection and primary progression infection processes is proposed. Global stability is examined using the geometric approach which involves the generalization of Poincare-Bendixson criterion for systems of n -ordinary differential equations. Analytical results show that for a Susceptible-Exposed-Infective-Recovered (SEIR) model incorporating exogenous reinfection and primary progression infection mechanisms, an additional condition is required to fulfill the Bendixson criterion for global stability. That is, the model is globally asymptotically stable whenever a parameter accounting for exogenous reinfection is less than the ratio of background mortality to effective contact rate. Numerical simulations are also presented to support theoretical findings.

scholarly journals Analysis of a Heroin Epidemic Model with Saturated Treatment Function

2017 ◽  
Vol 2017 ◽  
pp. 1-21 ◽  
Author(s):  
Isaac Mwangi Wangari ◽  
Lewi Stone
Keyword(s):  
Global Stability ◽  
Lyapunov Functions ◽  
Geometric Approach ◽  
Latin Hypercube Sampling ◽  
Heroin Addiction ◽  
Globally Asymptotically Stable ◽  
Heroin Users ◽  
Complete Representation ◽  
Effective Contact ◽  
Treatment Function

A mathematical model is developed that examines how heroin addiction spreads in society. The model is formulated to take into account the treatment of heroin users by incorporating a realistic functional form that “saturates” representing the limited availability of treatment. Bifurcation analysis reveals that the model has an intrinsic backward bifurcation whenever the saturation parameter is larger than a fixed threshold. We are particularly interested in studying the model’s global stability. In the absence of backward bifurcations, Lyapunov functions can often be found and used to prove global stability. However, in the presence of backward bifurcations, such Lyapunov functions may not exist or may be difficult to construct. We make use of the geometric approach to global stability to derive a condition that ensures that the system is globally asymptotically stable. Numerical simulations are also presented to give a more complete representation of the model dynamics. Sensitivity analysis performed by Latin hypercube sampling (LHS) suggests that the effective contact rate in the population, the relapse rate of heroin users undergoing treatment, and the extent of saturation of heroin users are mechanisms fuelling heroin epidemic proliferation.

scholarly journals Global stability of the endemic equilibrium and uniform persistence in epidemic models with subpopulations

1993 ◽  
Vol 34 (3) ◽  
pp. 282-295 ◽  
Author(s):  
Xiaodong Lin ◽  
Joseph W.-H. So
Keyword(s):  
Global Stability ◽  
Epidemic Model ◽  
Endemic Equilibrium ◽  
Epidemic Models ◽  
Uniform Persistence ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Contact Rates ◽  
Effective Contact

AbstractWe consider the epidemic model with subpopulations introduced in Hethcote [5]. It is shown that if the endemic equilibrium exists, then the system is uniformly persistent. Moreover, the endemic equilibrium is globally asymptotically stable under the assumption of small effective contact rates between different subpopulations.

scholarly journals Kestabilan Global Endemik Model Epidemi SEIR

2014 ◽  
Vol 9 (2) ◽  
pp. 52
Author(s):  
Roni Tri Putra ◽  
Sukatik - ◽  
Sri Nita ◽  
Yandraini Yunida
Keyword(s):  
Global Stability ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Equilibrium Points ◽  
Endemic Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Seir Model ◽  
Stability Of Equilibrium ◽  
The Basic Reproduction Number

In this paper, it will be studied global stability endemic of equilibrium points of  a SEIR model with infectious force in latent, infected and immune period. From the model it will be found investigated the existence and its stability of points its equilibrium. The global stability of equilibrium points is depending on the value of the basic reproduction number  If   there is a unique endemic equilibrium which is globally asymptotically stable.

scholarly journals Global Stability of a Host-Vector Model for Pine Wilt Disease with Nonlinear Incidence Rate

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Kwang Sung Lee ◽  
Abid Ali Lashari
Keyword(s):  
Global Stability ◽  
Pine Wilt Disease ◽  
Geometric Approach ◽  
Wilt Disease ◽  
Endemic Equilibrium ◽  
Vector Model ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Pine Wilt ◽  
Disease Free

Based on classical epidemic models, this paper considers a deterministic epidemic model for the spread of the pine wilt disease which has vector mediated transmission. The analysis of the model shows that its dynamics are completely determined by the basic reproduction numberR0. Using a Lyapunov function and a LaSalle's invariant set theorem, we proved the global asymptotical stability of the disease-free equilibrium. We find that ifR0≤1, the disease free equilibrium is globally asymptotically stable, and the disease will be eliminated. IfR0>1, a unique endemic equilibrium exists and is shown to be globally asymptotically stable, under certain restrictions on the parameter values, using the geometric approach method for global stability, due to Li and Muldowney and the disease persists at the endemic equilibrium state if it initially exists.

scholarly journals Stability analysis of a dynamical model of tuberculosis with incomplete treatment

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Ihsan Ullah ◽  
Saeed Ahmad ◽  
Qasem Al-Mdallal ◽  
Zareen A. Khan ◽  
Hasib Khan ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Contact Rate ◽  
Asymptotically Stable ◽  
Treatment Rate ◽  
Globally Asymptotically Stable ◽  
Reproduction Ratio ◽  
Efficient Treatment ◽  
Effective Contact ◽  
The Impact ◽  
Incomplete Treatment

Abstract A simple deterministic epidemic model for tuberculosis is addressed in this article. The impact of effective contact rate, treatment rate, and incomplete treatment versus efficient treatment is investigated. We also analyze the asymptotic behavior, spread, and possible eradication of the TB infection. It is observed that the disease transmission dynamics is characterized by the basic reproduction ratio $\Re _{0}$ ℜ 0 ; if $\Re _{0}<1$ ℜ 0 < 1 , there is only a disease-free equilibrium which is both locally and globally asymptotically stable. Moreover, for $\Re _{0}>1$ ℜ 0 > 1 , a unique positive endemic equilibrium exists which is globally asymptotically stable. The global stability of the equilibria is shown via Lyapunov function. It is also obtained that incomplete treatment of TB causes increase in disease infection while efficient treatment results in a reduction in TB. Finally, for the estimated parameters, some numerical simulations are performed to verify the analytical results. These numerical results indicate that decrease in the effective contact rate λ and increase in the treatment rate γ play a significant role in the TB infection control.

scholarly journals Global Stability and Optimal Control of Dengue with Two Coexisting Virus Serotypes

MATEMATIKA ◽  
2019 ◽  
Vol 35 (4) ◽  
pp. 149-170
Author(s):  
Afeez Abidemi ◽  
Rohanin Ahmad ◽  
Nur Arina Bazilah Aziz
Keyword(s):  
Optimal Control ◽  
Global Stability ◽  
Disease Transmission ◽  
Deterministic Model ◽  
Control Strategies ◽  
Equilibrium Points ◽  
Effective Control ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Boundary Equilibrium

This study presents a two-strain deterministic model which incorporates Dengvaxia vaccine and insecticide (adulticide) control strategies to forecast the dynamics of transmission and control of dengue in Madeira Island if there is a new outbreak with a different virus serotypes after the first outbreak in 2012. We construct suitable Lyapunov functions to investigate the global stability of the disease-free and boundary equilibrium points. Qualitative analysis of the model which incorporates time-varying controls with the specific goal of minimizing dengue disease transmission and the costs related to the control implementation by employing the optimal control theory is carried out. Three strategies, namely the use of Dengvaxia vaccine only, application of adulticide only, and the combination of Dengvaxia vaccine and adulticide are considered for the controls implementation. The necessary conditions are derived for the optimal control of dengue. We examine the impacts of the control strategies on the dynamics of infected humans and mosquito population by simulating the optimality system. The disease-freeequilibrium is found to be globally asymptotically stable whenever the basic reproduction numbers associated with virus serotypes 1 and j (j 2 {2, 3, 4}), respectively, satisfy R01,R0j 1, and the boundary equilibrium is globally asymptotically stable when the related R0i (i = 1, j) is above one. It is shown that the strategy based on the combination of Dengvaxia vaccine and adulticide helps in an effective control of dengue spread in the Island.

scholarly journals Global Stability of Malaria Transmission Dynamics Model with Logistic Growth

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Abadi Abay Gebremeskel
Keyword(s):  
Sensitivity Analysis ◽  
Global Stability ◽  
Malaria Transmission ◽  
Equilibrium Points ◽  
Transmission Dynamics ◽  
Logistic Growth ◽  
Asymptotically Stable ◽  
Dynamics Model ◽  
Globally Asymptotically Stable ◽  
The Impact

Mathematical models become an important and popular tools to understand the dynamics of the disease and give an insight to reduce the impact of malaria burden within the community. Thus, this paper aims to apply a mathematical model to study global stability of malaria transmission dynamics model with logistic growth. Analysis of the model applies scaling and sensitivity analysis and sensitivity analysis of the model applied to understand the important parameters in transmission and prevalence of malaria disease. We derive the equilibrium points of the model and investigated their stabilities. The results of our analysis have shown that if R0≤1, then the disease-free equilibrium is globally asymptotically stable, and the disease dies out; if R0>1, then the unique endemic equilibrium point is globally asymptotically stable and the disease persists within the population. Furthermore, numerical simulations in the application of the model showed the abrupt and periodic variations.

A mathematical analysis of a tuberculosis epidemic model with two treatments and exogenous re-infection

2020 ◽  
pp. 2050082
Author(s):  
Mehdi Lotfi ◽  
Azizeh Jabbari ◽  
Hossein Kheiri
Keyword(s):  
Mathematical Model ◽  
Asymptotic Stability ◽  
Stable Disease ◽  
Reproduction Number ◽  
Geometric Approach ◽  
Backward Bifurcation ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Bifurcation Phenomenon ◽  
Disease Free

In this paper, we propose a mathematical model of tuberculosis with two treatments and exogenous re-infection, in which the treatment is effective for a number of infectious individuals and it fails for some other infectious individuals who are being treated. We show that the model exhibits the phenomenon of backward bifurcation, where a stable disease-free equilibrium coexists with a stable endemic equilibria when the related basic reproduction number is less than unity. Also, it is shown that under certain conditions the model cannot exhibit backward bifurcation. Furthermore, it is shown in the absence of re-infection, the backward bifurcation phenomenon does not exist, in which the disease-free equilibrium of the model is globally asymptotically stable when the associated reproduction number is less than unity. The global asymptotic stability of the endemic equilibrium, when the associated reproduction number is greater than unity, is established using the geometric approach. Numerical simulations are presented to illustrate our main results.

Global dynamics of hepatitis C viral infection with logistic proliferation

2016 ◽  
Vol 09 (04) ◽  
pp. 1650056
Author(s):  
Sandip Banerjee ◽  
Ram Keval ◽  
Sunita Gakkhar
Keyword(s):  
Mathematical Model ◽  
Hepatitis C Virus ◽  
Stability Analysis ◽  
Hepatitis C ◽  
Viral Infection ◽  
Global Stability ◽  
Geometric Approach ◽  
Global Dynamics ◽  
Viral Dynamics ◽  
Global Stability Analysis

A modified mathematical model of hepatitis C viral dynamics has been presented in this paper, which is described by four coupled ordinary differential equations. The aim of this paper is to perform global stability analysis using geometric approach to stability, based on the higher-order generalization of Bendixson’s criterion. The result is also supported numerically. An important epidemiological issue of eradicating hepatitis C virus has been addressed through the global stability analysis.

Global stability of an SEIR epidemic model with vaccination

2016 ◽  
Vol 09 (06) ◽  
pp. 1650082 ◽  
Author(s):  
Lili Wang ◽  
Rui Xu
Keyword(s):  
Global Stability ◽  
Basic Reproduction Number ◽  
Epidemic Model ◽  
Reproduction Number ◽  
Sufficient Conditions ◽  
Endemic Equilibrium ◽  
Globally Asymptotically Stable ◽  
Compound Matrices ◽  
Comparison Arguments ◽  
The Basic Reproduction Number

In this paper, an SEIR epidemic model with vaccination is formulated. The results of our mathematical analysis indicate that the basic reproduction number plays an important role in studying the dynamics of the system. If the basic reproduction number is less than unity, it is shown that the disease-free equilibrium is globally asymptotically stable by comparison arguments. If it is greater than unity, the system is permanent and there is a unique endemic equilibrium. In this case, sufficient conditions are established to guarantee the global stability of the endemic equilibrium by the theory of the compound matrices. Numerical simulations are presented to illustrate the main results.

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