Validity Range of Micropipette Radius in Using Hemispherical Cap Model

2013 ◽  
Vol 419 ◽  
pp. 587-592
Author(s):  
G.Y. Jiao ◽  
Ming Dao ◽  
C.H. Sow ◽  
C.T. Lim
Keyword(s):  
Mechanical Properties ◽  
Mathematical Model ◽  
Mechanical Model ◽  
Living Cells ◽  
Micropipette Aspiration ◽  
Post Processing ◽  
Element Simulation ◽  
Validity Range ◽  
Cap Model ◽  
Experiment Technique

Micropipette aspiration is a widely used experiment technique for studying mechanical properties of living cells. Its data can be processed in many different ways. Among them, a mathematical model called hemispherical cap model has been developed to evaluate the elastic modulus of the cell membrane undergoing micropipette aspiration. It has been commonly used in cell studies due to its simplicity and convenience. However, this mechanical model has its own assumptions and limitations. In this article, the authors used finite element simulation to obtain the validity range of micropipette radius used in hemispherical cap model. The results provide reliable size instructions in the preparation and post-processing of micropipette experiments.

Determination of Cellular Mechanical Properties by Cell Poking, With an Application to Leukocytes

1990 ◽  
Vol 112 (3) ◽  
pp. 283-294 ◽  
Author(s):  
G. I. Zahalak ◽  
W. B. McConnaughey ◽  
E. L. Elson
Keyword(s):  
Mechanical Properties ◽  
Final Section ◽  
Mechanical Response ◽  
Living Cells ◽  
Micropipette Aspiration ◽  
Current Status ◽  
Technical Description ◽  
Analytical Results ◽  
Simple Models

In this paper we review the cell-poking technique as an approach for investigating the mechanical properties of living cells. We first summarize the rationale for the technique and the mainly qualitative results obtained so far. Then we provide a technical description of the instrument as it is configured at present. This is followed by a discussion of the current status of analytical results available for interpreting cell-poking measurements. In the final section we apply these results to an analysis of unmodulated and modulated lymphocytes and neutrophils, and conclude that the mechanical response of these leukocytes to indentation is not consistent with simple models developed by previous investigators on the basis of micropipette-aspiration experiments.

Design and Simulation of Fully Mechanized Hydraulic Support

2014 ◽  
Vol 644-650 ◽  
pp. 199-202
Author(s):  
Pei Qin Wang ◽  
Zeng Shun Xu ◽  
Zuo Feng Sun ◽  
Hui Yuan Jiang
Keyword(s):  
Mechanical Properties ◽  
Mathematical Model ◽  
Mechanical Model ◽  
Simulation Analysis ◽  
Virtual Prototype ◽  
Dynamics Simulation ◽  
Prototype Model ◽  
Design Calculation ◽  
Hydraulic Support ◽  
Element Analysis

Based on theoretical calculation, virtual prototype technology and the method of finite element analysis, the fully mechanized hydraulic support is designed and simulated. Firstly, the four-link mechanism of hydraulic support mechanical model and mathematical model are established, the demission is confirmed by design calculation of structure. Secondly, through the establishment of rigid parameterized virtual prototype model of the system, dynamics simulation analysis and research is finished based on ADAMS on the mechanical properties. Finally, based on FEA, the modal calculation of key components is completed by using ANSYS.

The effect of pressure on the compressibility of aluminum alloys

2020 ◽  
pp. 102-107
Keyword(s):  
Mechanical Properties ◽  
Mathematical Model ◽  
Liquid Metal ◽  
Control Systems ◽  
Physical And Mechanical Properties ◽  
Reliable Data ◽  
Output Process ◽  
Automated Control ◽  
Input And Output ◽  
Crystallization Under Pressure

To obtain reliable data on the properties of liquid metal and create automated control systems, the technological process of molding with crystallization under pressure is studied. A mathematical model of the input and output process parameters is developed. It is established that the compressibility of the melt can represent the main controlled parameter influencing on the physical-mechanical properties of the final products. The obtained castings using this technology are not inferior in their physical and mechanical properties to those produced by forging or stamping.

ANSYS Simply Supported Deep Beams Based on the Study of Mechanical Properties

2013 ◽  
Vol 351-352 ◽  
pp. 782-785
Author(s):  
Yong Bing Liu ◽  
Xiao Zhong Zhang
Keyword(s):  
Mechanical Properties ◽  
Finite Element Analysis ◽  
Mechanical Model ◽  
Work Performance ◽  
Deep Beam ◽  
Analysis Software ◽  
Deep Beams ◽  
Element Analysis ◽  
Simply Supported ◽  
Force Characteristics

Established the mechanical model of simply supported deep beam, calculation and analysis of simple supported deep beams by using finite element analysis software ANSYS, simulated the force characteristics and work performance of the deep beam. Provides the reference for the design and construction of deep beams.

Mathematical Model of the Sintering Process of Iron-Copper Bearings

2007 ◽  
Vol 23 ◽  
pp. 119-122
Author(s):  
Cristina Teișanu ◽  
Stefan Gheorghe ◽  
Ion Ciupitu
Keyword(s):  
Experimental Data ◽  
Mechanical Properties ◽  
Mathematical Model ◽  
Regression Analysis ◽  
Function Optimization ◽  
Chemical Compositions ◽  
Sintering Process ◽  
Molybdenum Disulphide ◽  
Iron Copper ◽  
Antifriction Properties

The most important features of the self-lubricating bearings are the antifriction properties such as friction coefficient and wear resistence and some mechanical properties such as hardness, tensile strength and radial crushing strength. In order to improve these properties new antifriction materials based on iron-copper powders with several additional components (tin, lead and molybdenum disulphide) have been developed by PM techniques. To find the optimal relationship between chemical compositions, antifriction and mechanical properties, in this paper a mathematical model of the sintering process is developed, which highlighted the accordance of the model with data by regression analysis. For the statistical processing of the experimental data the VH5 hardness values of the studied materials were considered. The development of mathematical model includes the enunciation of the model, the establishment of the performance function (optimization) and the establishment of the model equations and verifying. The accordance of the model with experimental data has been highlighted by regression analysis

Analysis and Test on Mechanical Properties of a Flexible Suspension Bridge

2013 ◽  
Vol 405-408 ◽  
pp. 1616-1622
Author(s):  
Guo Hui Cao ◽  
Jia Xing Hu ◽  
Kai Zhang ◽  
Min He
Keyword(s):  
Mechanical Properties ◽  
Suspension Bridge ◽  
Experimental Results ◽  
Suspension Bridges ◽  
Loading Test ◽  
Main Cable ◽  
Element Simulation ◽  
Static Loading Test ◽  
Geometric Nonlinear Analysis ◽  
Test Process

In order to research on mechanical properties of flexible suspension bridges, a geometric nonlinear analysis method was used to simulate on the experimental results, and carried on static loading test finally. In the loading test process, the deformations were measured in critical section of the suspension bridge, and displacement values of measured are compared with simulation values of the finite element simulation. Meanwhile the deformations of the main cable sag are observed under classification loading, the results show that the main cable sag increment is basically linear relationship with the increment of mid-span loading and tension from 3L/8 and 5L/8 to L/2 section, the main cable that increasing unit sag required mid-span loads and tension are gradually reduce in near L/4 and 3L/4 sections and gradually increase in near L/8 and 7L/8 sections and almost equal in near L/2, 3L/8 and 5L/8 sections. From the experimental results, the flexible suspension bridge possess good mechanical properties.

scholarly journals Anisotropic Mechanical Properties of Living Cells Revealed by Integrated Spinning Disk Confocal and Atomic Force Microscopy

2018 ◽  
Vol 114 (3) ◽  
pp. 513a
Author(s):  
Yuri M. Efremov ◽  
Mirian Velay-Lizancos ◽  
Daniel M. Suter ◽  
Pablo D. Zavattieri ◽  
Arvind Raman
Keyword(s):  
Mechanical Properties ◽  
Atomic Force Microscopy ◽  
Living Cells ◽  
Force Microscopy ◽  
Atomic Force ◽  
Spinning Disk ◽  
Anisotropic Mechanical Properties

Study on Welding Deformation and Residual Stress of H-Section Beam Based on Finite Element Method

2017 ◽  
Vol 753 ◽  
pp. 305-309 ◽  
Author(s):  
Xu Lu
Keyword(s):  
Mechanical Properties ◽  
Residual Stress ◽  
Finite Element ◽  
Source Parameters ◽  
Welding Process ◽  
Steel Structure ◽  
Bottom Plate ◽  
Welding Deformation ◽  
Element Simulation ◽  
Main Components

The welding H-section beam has good mechanical properties with its superior structure. So they become the main components of steel structure and have been widely used. In this paper, the welded H-section beam is used as the research object. The finite element simulation model is established. The heat source parameters are determined. The deformation of the steel due to the welding process is studied. The results show that the bottom plate and the bottom plate inward bending is about 2.32mm cause by welding process. The residual stress can reach 400MPa.

scholarly journals Tailoring Microstructure and Mechanical Properties of Additively-Manufactured Ti6Al4V Using Post Processing

Materials ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 658
Author(s):  
Yaron Itay Ganor ◽  
Eitan Tiferet ◽  
Sven C. Vogel ◽  
Donald W. Brown ◽  
Michael Chonin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Electron Beam ◽  
Fatigue Resistance ◽  
Electron Beam Melting ◽  
High Reliability ◽  
National Laboratory ◽  
Post Processing ◽  
Proof Stress ◽  
Β Phase ◽  
Microstructure And Mechanical Properties

Additively-manufactured Ti-6Al-4V (Ti64) exhibits high strength but in some cases inferior elongation to those of conventionally manufactured materials. Post-processing of additively manufactured Ti64 components is investigated to modify the mechanical properties for specific applications while still utilizing the benefits of the additive manufacturing process. The mechanical properties and fatigue resistance of Ti64 samples made by electron beam melting were tested in the as-built state. Several heat treatments (up to 1000 °C) were performed to study their effect on the microstructure and mechanical properties. Phase content during heating was tested with high reliability by neutron diffraction at Los Alamos National Laboratory. Two different hot isostatic pressings (HIP) cycles were tested, one at low temperature (780 °C), the other is at the standard temperature (920 °C). The results show that lowering the HIP holding temperature retains the fine microstructure (~1% β phase) and the 0.2% proof stress of the as-built samples (1038 MPa), but gives rise to higher elongation (~14%) and better fatigue life. The material subjected to a higher HIP temperature had a coarser microstructure, more residual β phase (~2% difference), displayed slightly lower Vickers hardness (~15 HV10N), 0.2% proof stress (~60 MPa) and ultimate stresses (~40 MPa) than the material HIP’ed at 780 °C, but had superior elongation (~6%) and fatigue resistance. Heat treatment at 1000 °C entirely altered the microstructure (~7% β phase), yield elongation of 13.7% but decrease the 0.2% proof-stress to 927 MPa. The results of the HIP at 780 °C imply it would be beneficial to lower the standard ASTM HIP temperature for Ti6Al4V additively manufactured by electron beam melting.

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