Dicarbonyl compounds in the synthesis of heterocycles under green conditions

Carbon–carbon and carbon-heteroatom bond forming reactions are strategically employed for the generation of a variety of heterocyclic systems. This class of compounds represents the most general structural unit, present in many natural compounds. They are recognized for their valuable biologically properties and wide range of applications in medicinal, pharmaceutical, and other related fields of chemistry. This is an updated review on the use of dicarbonyl compounds under environmentally friendly conditions to access a series of heterocyclic structures, e.g., quinoxaline, quinazolinones, benzochalcogenazoles, indoles, among others. Synthetic protocols involving copper-catalyzed, multicomponent and cascade reactions, decarboxylative cyclization, recycling of CO2, and electrochemical approaches are presented and discussed.

The X-ray, Raman and TEM Signatures of Cellulose-Derived Carbons Explained

Structural properties of carbonized cellulose were explored to conjugate the outcomes from various characterization techniques, namely X-ray diffraction (XRD), Raman spectroscopy, and high-resolution transmission electron microscopy. All these techniques have evidenced the formation of graphene stacks with a size distribution. Cellulose carbonized at 1000 and 1800 °C at a heating rate of 2 °C/min showed meaningful differences in Raman spectroscopy, whereas in XRD, the differences were not well pronounced, which implies that the crystallite sizes calculated by each technique have different significations. In the XRD patterns, the origin of a specific feature at a low scattering angle commonly reported in the literature but poorly explained so far, was identified. The different approaches used in this study were congruous in explaining the observations that were made on the cellulose-derived carbon samples. The remnants of the basic structural unit (BSU) are developed during primary carbonization. Small graphene-based crystallites inherited from the BSUs, which formerly developed during primary carbonization, were found to coexist with larger ones. Even if the three techniques give information on the average size of graphenic domains, they do not see the same characteristics of the domains; hence, they are not identical, nor contradictory but complementary. The arguments developed in the work to explain which characteristics are deduced from the signal obtained by each of the three characterization techniques relate to physics phenomena; hence, they are quite general and, therefore, are valid for all kind of graphenic materials.

STRENGTH ANALYSIS OF SCREW CONVEYOR DRIVE

The present paper deals with research of strength characteristics in manufacturing engineering. The introduction of the work describes findings about the importance of the given subject. The publication is divided into two basic parts, namely the theoretical and the practical part. The theoretical part provides a detailed description of theoretical assumptions on solutions in the field of research, and it also describes optimization of structural units in manufacturing engineering, while the practical part analyses strength characteristics of the selected structural unit which is the drive of a manufacturing machine. The conclusion of the work presents the obtained results.

Bias deployable grids with horizontal compound scissor-like elements: A geometric study of the folding/deployment process

Bias deployable structural units are two-way structures arranged in a rotational pattern with respect to the edges. They have interesting advantages such as robust three-dimensional operation with supports around their entire base perimeter and the exclusive use of load-bearing scissor-like elements (SLEs). However, they do not have edge trims and their resistance to angular distortion is limited. This article proposes a series of deployable bi-stable structures that address these problems and incorporate new, resilient features. A method of analysing the incompatibilities of the structural unit is developed based solely on the geometric study of the deployment process, which allows the level of incompatibility of the proposal to be graduated, varying from stress-free structures to bi-stable structures. A kinematic model of one of the proposals allows the research undertaken to be contrasted.

Entropy Analysis of Protein Sequences Reveals a Hierarchical Organization

Background: Analyzing the local sequence content in proteins, earlier we found that amino acid residue frequencies differ on various distances between amino acid positions in the sequence, assuming the existence of structural units. Methods: We used informational entropy of protein sequences to find that the structural unit of proteins is a block of adjacent amino acid residues—“information unit”. The ANIS (ANalysis of Informational Structure) method uses these information units for revealing hierarchically organized Elements of the Information Structure (ELIS) in amino acid sequences. Results: The developed mathematical apparatus gives stable results on the structural unit description even with a significant variation in the parameters. The optimal length of the information unit is five, and the number of allowed substitutions is one. Examples of the application of the method for the design of protein molecules, intermolecular interactions analysis, and the study of the mechanisms of functioning of protein molecular machines are given. Conclusions: ANIS method makes it possible not only to analyze native proteins but also to design artificial polypeptide chains with a given spatial organization and, possibly, function.

Funding in the budgetary institution as a factor of staff satisfaction

The article considers the peculiarities of labor financing in a budgetary institution through the lens of staff satisfaction with working conditions, which is one of the priority goals of the organization’s personnel policy. The article presents a methodology for assessing staff satisfaction with work in a budget institution, which allows you to identify «problem zones» and improve working conditions. The authors tested the proposed technique. The proposed methodology is based on a comprehensive approach, which takes into account working conditions, financing, labor content and interaction of employees within the structural unit. As a result of the development of the methodology, a model of interaction of the department with other structural divisions of the educational organization was proposed.The purpose of the model is to identify relationships between business units to optimize and balance the interests of all participants. The interaction of structural divisions is carried out with the aim of organizing the educational process and research activities, exchanging experience, building interdisciplinary ties, and implementing comprehensive scientific research. The organization of interaction between faculties allows you to integrate the research base an

Channelopathies an Approach to Elevate Level of Cure- A Review

Channelopathies is group of diseases which is concerned with changes occur in the structural unit i.e., cell and its subunits (channels). Particularly disturbances in equilibrium potential in cell membrane carry toward the major cause of disease. Study of channel physiology with its mechanism is essential methodology to establish the differential factor in between normal phenomenon and disorder. Specific channels permit movement of selected ions through cellular membranes and are of important importance during variety of physiological processes, particularly in excitable tissues. In this review channelopathies in diseases like Central nervous system, Cardiovascular system, Renal system with their mechanism of action of channel disruption and treatment approaches have been covered.

PHYSIOLOGICAL ASPECTS OF ASTHIDHATU

Ayurveda is an ancient medical science which is related to health. Ayurveda described three basic physiological constitution of the body they are: Dosha, Dhatu and mala. Dhatu are structural unit of the body. Asthi is fifth dhatu among saptadhatu. In modern science asthidhatu relate with bones and cartilage. Bones store minerals such as calcium. Metabolic bone diseases are caused by minerals and vitamins deficiency. Asthidhatu is resultant of action of medoagni on medodhatu and is responsible for nourishing majjadhatu. It supports the basic structures, protect vital organs, nourishing the nervous tissue. Health refers to the moderate quantity of asthidhatu while dis- orders may develop when any vitiation occur. Just as asthi dhatu (Bones) contribute to health, diseases related to bones can disrupt the body. This paper attempts to understand concepts of Asthidhatu for maintain health and pre- vention from diseases related to the bone. Keywords: Health, Asthidhatu ksaya-Vruddhi, functions