Although a variety of ocean mesoscale eddy datasets are available for researchers to study eddy properties throughout the global ocean, subtle differences in how these datasets are produced often lead to large differences between one another. This study compares the Global Ocean Mesoscale Eddy Atmospheric-Oceanic-Biological interaction Observational Dataset (GOMEAD) with the well-recognized Mesoscale Eddy Trajectory Atlas in four regions with strong eddy activity: the Northwest Pacific Subtropical Front (SF), Kuroshio Extension (KE), South China Sea (SCS), and California Coastal Current (CC), and assesses the relative advantages and disadvantages of each. It was identified that while there is a slight difference in the total number of eddies detected in each dataset, the frequency distribution of eddy radii presents a right-skewed normal distribution, tending towards larger radii eddies, and there are more short- than long-lived eddies. Interestingly, the total number of GOMEAD eddies is 8% smaller than in the META dataset and this is most likely caused by the GOMEAD dataset’s underestimation of total eddy numbers and lifespans due to their presence near islands, and the tendency to eliminate eddies from its database if their radii are too small to be adequately detected. By contrast, the META dataset, due to tracking jumps in detecting eddies, may misidentify two eddies as a single eddy, reducing total number of eddies detected. Additionally, because the META dataset is reliant on satellite observations of sea surface level anomalies (SLAs), when SLAs are weak, the META dataset struggles to detect eddies. The GOMEAD dataset, by contrast, is reliant on applying vector geometry to detect and track eddies, and thus, is largely insulated from this problem. Thus, although both datasets are excellent in detecting and characterizing eddies, users should use the GOMEAD dataset when the region of interest is far from islands or when SLAs are weak but use the META dataset if the region of interest is populated by islands, or if SLAs are intense.