Forest fires triggered by various natural and anthropogenic drivers are increasing and threatening forest ecosystems across the globe. In Nepal, the high value Tropical Mixed Broad-leaved Forests are prone to fire caused by both natural and anthropogenic drivers. Thus, understanding fire drivers and their effect is important for the sustainable forest fire management. However, the preceding studies on forest specific fire drivers and their effect are limited. This research has identified the fire drivers and assessed their effect to fire occurrences in the Tropical Mixed Broad-leaved Forests of Nawalparasi District, Nepal. Fire drivers were identified and prioritized by participatory approaches. The fire incidences and burnt areas were obtained from the MODIS fire data (2001–2017). The results revealed altogether 20 drivers including eight natural and 12 anthropogenic. Based on the public perception and magnitude of forest fire, among the natural drivers, temperature, precipitation, forest fuel, aspect, elevation and slope were the major drivers. Likewise, among the anthropogenic drivers, forest distance from roads and settlements showed significant effect. The natural drivers, ambient temperature >30ºC and annual precipitation <2400 mm, revealed signi-ficant impacts on forest fire. Likewise, forests situated at lower elevation (<500 m), and southern and eastern aspects were highly vulnerable to fire. Considering anthropogenic drivers, forest lying within 500 m from the roads and settlements were highly vulnerable to fire. Among the forest types, the Hill Sal Forest was more affected. Future strategies should address the major fire drivers, construction of adequate fire lines and conservation ponds for the sustainable forest management.