SIMULTANEOUS ESTIMATION OF AZILSARTAN AND CILNIDIPINE IN BULK BY RP-HPLC AND ASSESSMENT OF ITS APPLICABILITY IN MARKETED TABLET DOSAGE FORM

Objective: This study aims to build up the RP-HPLC process for Azilsartan and Cilnidipine and authenticate the RP-HPLC process according to ICH validation code Q2R1. Methods: System suitability testing was performed to discover the qualifying criterion of the method by injecting the identical standard solution of Azilsartan 40μg/ml and Cilnidipine 10μg/ml in mixture/combination in subsequent optimized chromatographic conditions and the chromatogram was recorded. Moreover, the planned method was validated as per ICH guideline Q2R1 for the following parameters: linearity and range, precision, accuracy, robustness, and determined % recovery. Results: The outcomes of %RSD for retention time and peak area were found to be 0.65 and 1.32 for Azilsartan and 0.85 and 1.90 for Cilnidipine. The correlation coefficient, y-intercept, slope of the regression line were 0.9996,-1127.1, 3313.9, and 0.9993, 1460.2, 2876.4 for Azilsartan and Cilnidipine, respectively. Moreover, the range of this method was observed to be 40-240μg/ml and 10-60 μg/ml for Azilsartan and Cilnidipine, standard concentrations respectively. The % RSD achieved for precision (repeatability) was observed in the range of 1.57 to 2.43 for Azilsartan and 0.70 to 1.88 for Cilnidipine. The % accuracy was found in the range of 96.96 to 101.92% w/w for Azilsartan and 99.19 to101.96%w/w for Cilnidipine. The percent recovery values achieved for Azilsartan were in the range of 99.87 to 106.39% w/w and for Cilnidipine in the range of 94.51 to 105.96% w/w. Conclusion: The author concludes that the simultaneous estimation of Azilsartan and Cilnidipine with predefined objectives was successfully achieved. Moreover, the method was found to be steadfast for the quantification of Azilsartan and Cilnidipine in marketed tablet dosage forms.

Validasi Metode Analisis Matriks Patch Domperidon Maleat dengan Perbedaan Polimer Menggunakan Spektorfotometri UV-Vis

Uv-Vis spectrophotometry is an analytical method that can be used to determine the levels of domperidon maleate contained in transdermal patches with different polymers. The analysis method needs to be validated to prove that it can provide measurement results that match its designation. The purpose of this study is to prove that uv-vis spectrophotometry methods can provide the specificity, linearity, thoroughness, and precision that meet the requirements. In this study, linearity was known by calculating the r value on the curve of the relationship between levels and absorbance. Precision is obtained based on rsd value. Accuracy is calculated based on the return value. Selectiveity is known by means of identity confirmation that calculates the absorbance ratio at different wavelengths. The results showed that the method meets the requirements with a value of r=0.999; RSD precision results at a level of 10 ppm obtained RSD 0.236%. The accuracy values of 80%, 100%, and 120% in the matrix of transdermal domperidon maleate patches with PVA and PVP polymers respectively recovery was 99.50%, 101.15%, and 99.13%.. In the matrix of transdermal patches domperidon maleate with polymers HPMC and Na-CMC respectively recovery was 100.91%, 100.31%, and 100.67%. In the matrix of transdermal domperidon patches with HPMC and EC polymers respectively recovery was 98.00%, 98.00%, and 99.00%. The identity confirmation results on the transdermal domperidon patch matrix with PVA and PVP polymers, HPMC and Na-CMC, as well as HPMC and EC respectively have ratio value close to the standard solution with an average value of 0.800; 0,806; and 0.808. It can be concluded that the method of analyzing the levels of domperidone maleate in matrix of transdermal patches has qualified for good validity.

PRELIMINARY DESIGN OF ANALOG DISCRETE UNIFORM NOISE GENERATOR

The paper presents the basic idea of ​​the construction of an analog discrete uniform noise generator. The source of noise is a carbon resistor, the noise is linearly strongly amplified and limited to around zero. The probability density function (PDF) of the carbon resistor thermal noise in that region is square. By narrowing the symmetric allowable gap (interval) around zero, PDF of the noise approaches a uniform distribution. The factor of deviation from the uniform distribution is correctly and precisely defined. This quantity has been shown to be practically negligible. In addition, the paper discusses the application of the proposed ditheter noise, both in the two-bit and in the multi-bit stochastic digital measurement method (SDMM). It has been shown that noise is more suitable for application in multi-bit SDMM, because it is less sensitive to deviations from the uniform distribution. Commercially available track-and-hold circuits provide at least an order of magnitude wider bandwidth of the described generator compared to the standard solution that uses numerical random number generator and a corresponding D/A converter. However, the realization of such a generator requires hard engineering work, and therefore goes beyond the scope of this paper.

GBTX emulator for development and special versions of GBT-based readout chains

The GBTX ASIC is a standard solution for providing fast control and data readout for radiation detectors used in HEP experiments. However, it is subject to export control restrictions due to the usage of radiation-hard technology. An FPGA-based GBTX emulator (GBTxEMU) has been developed to enable the development of GBT-based readout chains in countries where the original GBTX cannot be imported. Thanks to utilizing a slightly modified GBT-FGPA core, it maintains basic compatibility with standard GBT-based systems. The GBTxEMU also may be an interesting solution for developing GBT-based readout chains for less demanding experiments.

Effect of Boiling on Carotenoids content of Pumpkin available in Damascus, Syria

The carotenoids contents of pumpkin were determined in this study by spectrophotometric method. This method was applied on beta-carotene as standard solution as well as samples. The absorption were determined at λmax 454 nm, the analytical method was validated by evaluating linearity, precision, accuracy, LODs, and LOQs of the analyts. Beer’s law is obeyed over the concentration of (0.3-9) µg/ml with a linear regression correlation coefficient of 0.9986, and recovery in range from 98.5-102.2%. After the validation was performed using standard solution, the method then was applied on samples of pumpkin available in local market in Syria after extraction the carotenoids by using Acetone/ Dichloromethane 70/30 .The results ranged between 216.46 - 80.56 µg/g. During boiling for pumpkin, the level of carotenoid reduced between 0.45-13.26 %, 0.18 – 23.07%, 17.3-40.54%, 22.65-51.73%, 14.91_55.82% and 26.16 – 72.56%, for 5, 10, 15, 30, 45 and 60 min respectively. According to the obtained result results, it is concluded that the boiling reduced carotenoid at different rates.

Effect of Overheating Temperature on Thermal Cycling Creep Properties of K465 Superalloy

Turbine blades in aircraft engines may encounter overheating and suffer serious creep property degradation. In this study, the thermal cycling creep experiments were conducted on K465 superalloy under (900 °C/30 min–1100 °C/3 min)/50 MPa, (900 °C/30 min–1150 °C/3 min)/50 MPa and (1000 °C/30 min–1150 °C/3 min)/50 MPa. The investigated thermal cycling creep properties were dramatically degraded, and increasing the overheating temperatures significantly decreased the thermal cycling creep life. The secondary γ′ precipitates obviously dissolved and the area fraction decreased to around 35.2% under (900 °C/30 min–1150 °C/3 min)/50 MPa and (1000 °C/30 min–1150 °C/3 min)/50 MPa, which was almost half that after the standard solution treatment. The decline of the thermal cycling creep properties was mainly due to the significant dissolution of γ′ precipitates. The creep holes/cracks were mainly distributed at the M6C carbides and γ/γ′ eutectics interfaces, M6C carbides and γ′ film interfaces in the grain boundaries, and resulted in the final intergranular fracture.

A Hybrid Recommender System for HCI Design Pattern Recommendations

User interface design patterns are acknowledged as a standard solution to recurring design problems. The heterogeneity of existing design patterns makes the selection of relevant ones difficult. To tackle these concerns, the current work contributes in a twofold manner. The first contribution is the development of a recommender system for selecting the most relevant design patterns in the Human Computer Interaction (HCI) domain. This system introduces a hybrid approach that combines text-based and ontology-based techniques and is aimed at using semantic similarity along with ontology models to retrieve appropriate HCI design patterns. The second contribution addresses the validation of the proposed recommender system regarding the acceptance intention towards our system by assessing the perceived experience and the perceived accuracy. To this purpose, we conducted a user-centric evaluation experiment wherein participants were invited to fill pre-study and post-test questionnaires. The findings of the evaluation study revealed that the perceived experience of the proposed system’s quality and the accuracy of the recommended design patterns were assessed positively.

A Secure Recommendation System for Providing Context-Aware Physical Activity Classification for Users

Advances in Wireless Body Area Networks, where embedded accelerometers, gyroscopes, and other sensors empower users to track real-time health data continuously, have made it easier for users to follow a healthier lifestyle. Various other apps have been intended to choose suitable physical exercise, depending on the current healthcare environment. A Mobile Application (Mobile App) based recommendation system is a technology that allows users to select an apt activity that might suit their preferences. However, most of the current applications require constant input from end-users and struggle to include those who have hectic schedules or are not dedicated and self-motivated. This research introduces a methodology that uses a “Selective Cluster Cube” recommender system to intelligently monitor and classify user behavior by collecting accelerometer data and synchronizing with its calendar. We suggest customized daily workouts based on historical user and related user habits, interests, physical status, and accessibility. Simultaneously, the exposure of customer requirements to the server is also a significant concern. Developing privacy-preserving protocols with basic cryptographic techniques (e.g., protected multi-party computing or HE) is a standard solution to address privacy issues, but in combination with state-of-the-art advising frameworks, it frequently provides far-reaching solutions. This paper proposes a novel framework, a Privacy Protected Recommendation System (PRIPRO), that employs HE for securing private user data. The PRIPRO model is compared for accuracy and robustness using standard evaluation parameters against three datasets.

Determination of Halogens by Ion Chromatography in Edible Mushrooms after Microwave-Induced Combustion for Sample Preparation

In this study, the microwave-induced combustion (MIC) method was evaluated for the sample preparation of the most consumed mushroom species in Brazil (Champignon, Shiitake, and Shimeji) and further halogen determination by ion chromatography (IC). For this, sample mass, combustion aid mass, and absorbing solution (H2O and 50 mmol·L−1, 100 mmol·L−1, or 150 mmol·L−1 NH4OH) were evaluated. Bromine and iodine concentrations, determined by IC, were lower than the limits of detection (LODs, Br: 6 mg·kg−1 and I: 24 mg·kg−1). Inductively coupled plasma mass spectrometry (ICP-MS) was also used for Br and I determination, and the LODs were lower (Br: 0.066 mg·kg−1 and I: 0.014 mg·kg−1) than those obtained by IC. Concentrations of Cl, obtained by IC, ranged from 523 mg·kg−1 to 13053 mg·kg−1 with LOD of 40 mg·kg−1. In turn, Br and I concentrations, obtained by ICP-MS, ranged from 2.49 mg·kg−1 to 5.50 mg·kg−1 and from <0.014 mg·kg−1 to 0.047 mg·kg−1, respectively. Fluorine concentrations, determined by IC, were always lower than LOD (23 mg·kg−1). The trueness of the proposed methods was evaluated by recovery tests using standard solutions and a reference material (RM NIST 8435). When using the standard solution, recoveries ranged from 95% to 103% for halogen determination by IC and from 105% to 109% for Br and I determination by ICP-MS. When using the RM, recoveries of 102% for Cl by IC and of 87% and 86% for Br and I by ICP-MS, respectively, were obtained.