<p>Continued scientific study has revealed that land use and land cover change play a key role in climate and that the application of irrigation is an important biogeophysical contributor to climate modification across spatial scales. The Great Plains Irrigation Experiment (GRAINEX) was conducted in the spring and summer of 2018 to investigate Land-Atmosphere interactions just prior to and through the growing season across adjacent, but distinctly unique, soil moisture regimes (contrasting irrigated and rainfed fields). GRAINEX was uniquely designed for the development and analysis of an extensive observational dataset for comprehensive process studies of Land-Atmosphere interactions, by focusing on irrigated and rainfed croplands in a ~100 x 100 km domain in southeastern Nebraska. Observation platforms included multiple NCAR EOL Integrated Surface Flux Systems and Integrated Sounding Systems, NCAR CSWR Doppler Radar on Wheels, 1200 radiosonde balloon launches from 5 sites, the NASA GREX airborne L-Band radiometer, and 75 University of Alabama-Huntsville Environmental Monitoring Economic Monitoring Sensor Hubs<strong> </strong>(EMESH mesonet stations). The presentation will provide an overview of the field campaign, the dataset collected, and investigate the contrast of L-A intractions across an irrigation gradient through observations and mesoscale/microscale modeling on timescales ranging from the diurnal to the seasonal. Attention will be given to how variations in the land surface state, as a function of irrigation fraction, impacts near-surface meteorology and atmospheric boundary layer evolution at local and regional scales.</p>